{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:23:25Z","timestamp":1790346205679,"version":"4.1.0"},"reference-count":43,"publisher":"Korean Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6-2019-0102"],"award-info":[{"award-number":["6-2019-0102"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean Endocrine Society"},{"name":"Severance Hospital"}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2021,12,31]]},"abstract":"<jats:p>Background: A decrease in computed tomography (CT)-derived skeletal muscle radiodensity (SMD) reflects age-related ectopic fat infiltration of muscle, compromising muscle function and metabolism. We investigated the age-related trajectory of SMD and its association with vertebral trabecular bone density in healthy adults.Methods: In a cohort of healthy adult kidney donors aged 19 to 69 years (&lt;i&gt;n&lt;\/i&gt;=583), skeletal muscle index (SMI, skeletal muscle area\/height2), SMD, and visceral-to-subcutaneous fat (V\/S) ratio were analyzed at the level of L3 from preoperative CT scans. Low bone mass was defined as an L1 trabecular Hounsfield unit (HU) &lt;160 HU.Results: L3SMD showed constant decline from the second decade (annual change \u20130.38% and \u20130.43% in men and women), whereas the decline of L3SMI became evident only after the fourth decade of life (\u20130.37% and \u20130.18% in men and women). One HU decline in L3SMD was associated with elevated odds of low bone mass (adjusted odds ratio, 1.07; 95% confidence interval, 1.02 to 1.13; &lt;i&gt;P&lt;\/i&gt;=0.003), independent of L3SMI, age, sex, and V\/S ratio, with better discriminatory ability compared to L3SMI (area under the receiver-operating characteristics curve 0.68 vs. 0.53, &lt;i&gt;P&lt;\/i&gt;&lt;0.001). L3SMD improved the identification of low bone mass when added to age, sex, V\/S ratio, and L3SMI (category-free net reclassification improvement 0.349, &lt;i&gt;P&lt;\/i&gt;&lt;0.001; integrated discrimination improvement 0.015, &lt;i&gt;P&lt;\/i&gt;=0.0165).Conclusion: L3SMD can be an early marker for age-related musculoskeletal changes showing linear decline throughout life from the second decade in healthy adults, with potential diagnostic value for individuals with low bone mass.<\/jats:p>","DOI":"10.3803\/enm.2021.1206","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:46:16Z","timestamp":1639356376000},"page":"1201-1210","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Computed Tomography-Derived Skeletal Muscle Radiodensity Is an Early, Sensitive Marker of Age-Related Musculoskeletal Changes in Healthy 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