{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:56:37Z","timestamp":1793156197261,"version":"4.5.0"},"reference-count":53,"publisher":"Korean Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1F1A1070028"],"award-info":[{"award-number":["2020R1F1A1070028"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and ICT"},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI21C0940"],"award-info":[{"award-number":["HI21C0940"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2022,10,31]]},"abstract":"<jats:p>The fifth edition of the World Health Organization (WHO) histologic classification of thyroid neoplasms released in 2022 includes newly recognized tumor types, subtypes, and a grading system. Follicular cell-derived neoplasms are categorized into three families (classes): benign tumors, low-risk neoplasms, and malignant neoplasms. The terms \u201cfollicular nodular disease\u201d and \u201cdifferentiated high-grade thyroid carcinoma\u201d are introduced to account for multifocal hyperplastic\/neoplastic lesions and differentiated thyroid carcinomas with high-grade features, respectively. The term \u201cH\u00fcrthle cells\u201d is replaced with \u201concocytic cells.\u201d Invasive encapsulated follicular and cribriform morular variants of papillary thyroid carcinoma (PTC) are now redefined as distinct tumor types, given their different genetic alterations and clinicopathologic characteristics from other PTC subtypes. The term \u201cvariant\u201d to describe a subclass of tumor has been replaced with the term \u201csubtype.\u201d Instead, the term \u201cvariant\u201d is reserved to describe genetic alterations. A histologic grading system based on the mitotic count, necrosis, and\/or the Ki67 index is used to identify high-grade follicular-cell derived carcinomas and medullary thyroid carcinomas. The 2022 WHO classification introduces the following new categories: \u201csalivary gland-type carcinomas of the thyroid\u201d and \u201cthyroid tumors of uncertain histogenesis.\u201d This review summarizes the major changes in the 2022 WHO classification and their clinical relevance.<\/jats:p>","DOI":"10.3803\/enm.2022.1553","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T04:32:18Z","timestamp":1664857938000},"page":"703-718","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":281,"title":["Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach"],"prefix":"10.3803","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-3708","authenticated-orcid":true,"given":"Chan 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