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Endocrine disorders like obesity, diabetes, and Cushing\u2019s syndrome disrupt this balance, contributing to systemic inflammation and global health burdens. They accompany metabolic changes on multiple levels from molecular interactions to individual organs to the whole body. Understanding how metabolic fluxes relate to endocrine disorders illuminates the underlying dysregulation. Cancer is increasingly considered a systemic disorder because it not only affects cells in localized tumors but also the whole body, especially in metastasis. In tumorigenesis, cancer-specific mutations and nutrient availability in the tumor microenvironment reprogram cellular metabolism to meet increased energy and biosynthesis needs. Cancer cachexia results in metabolic changes to other organs like muscle, adipose tissue, and liver. This review explores the interplay between the endocrine system and systems-level metabolism in health and disease. We highlight metabolic fluxes in conditions like obesity, diabetes, Cushing\u2019s syndrome, and cancers. Recent advances in metabolomics, fluxomics, and systems biology promise new insights into dynamic metabolism, offering potential biomarkers, therapeutic targets, and personalized medicine.<\/jats:p>","DOI":"10.3803\/enm.2023.1814","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T08:17:27Z","timestamp":1700554647000},"page":"619-630","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer"],"prefix":"10.3803","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-9212","authenticated-orcid":true,"given":"Aliya","family":"Lakhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da 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