{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:46:56Z","timestamp":1785350816733,"version":"3.55.0"},"reference-count":17,"publisher":"Korean Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Takeda Pharmaceuticals"},{"name":"Kyowa Kirin"},{"name":"Ascendis Pharma"},{"name":"Calcillitix Therapeutics"},{"name":"Amolyt"}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:p>The conventional treatment of hypoparathyroidism (HypoPT) includes active vitamin D and calcium. Despite normalization of calcium levels, the conventional treatment is associated with fluctuations in calcium levels, hypercalciuria, renal impairment, and decreased quality of life (QoL). Replacement therapy with parathyroid hormone (PTH)(1-84) is an option in some countries. However, convincing beneficial effects have not been demonstrated, which may be due to the short duration of action of this treatment. Recently, palopegteriparatide (also known as TransCon PTH) has been marketed in Europe and is expected also to be approved in other countries. Palopegteriparatide is a prodrug with sustained release of PTH(1-34) designed to provide stable physiological PTH levels for 24 hours\/day. A phase 3 study demonstrated maintenance of normocalcemia in patients with chronic HypoPT, with no need for conventional therapy. Furthermore, this treatment lowers urinary calcium and improves QoL. Another long-acting PTH analog with effects on the parathyroid hormone receptor (eneboparatide) is currently being tested in a phase 3 trial. Furthermore, the treatment of autosomal dominant hypocalcemia type 1 with a calcilytic (encaleret) is also being tested. All in all, improved treatment options are on the way that will likely take the treatment of HypoPT to the next level.<\/jats:p>","DOI":"10.3803\/enm.2024.1916","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T07:57:40Z","timestamp":1712217460000},"page":"262-266","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Treatment of Hypoparathyroidism by Re-Establishing the Effects of Parathyroid Hormone"],"prefix":"10.3803","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-4247","authenticated-orcid":true,"given":"Lars","family":"Rejnmark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2119","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-01858-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.55"},{"key":"ref3","first-page":"2663","volume-title":"Management of hypoparathyroidism","author":"Khan","year":"2022"},{"key":"ref4","first-page":"R33","volume-title":"European expert consensus on practical management of specific aspects of parathyroid disorders in adults and in pregnancy: recommendations of the ESE educational program of parathyroid disorders","author":"Bollerslev","year":"2022"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(13)70106-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00893"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2552"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.10.3480"},{"key":"ref9","first-page":"391","volume-title":"Synthetic human parathyroid hormone 1-34 replacement therapy: a randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism","author":"Winer","year":"2012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.04.060"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3824"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab577"},{"key":"ref13","first-page":"14","volume-title":"Efficacy and safety of parathyroid hormone replacement with TransCon PTH in hypoparathyroidism: 26-week results from the phase 3 PaTHway trial","author":"Khan","year":"2023"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2811"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad114.562"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/mnh.0000000000000042"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc2302708"}],"container-title":["Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.e-enm.org\/upload\/pdf\/enm-2024-1916.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2024.1916","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.e-enm.org\/upload\/pdf\/enm-2024-1916.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T05:54:04Z","timestamp":1714456444000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2024.1916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.3803\/enm.2024.1916","relation":{},"ISSN":["2093-596X","2093-5978"],"issn-type":[{"value":"2093-596X","type":"print"},{"value":"2093-5978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]},"assertion":[{"value":"2023-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-04","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}