{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:40:43Z","timestamp":1790469643879,"version":"4.1.0"},"reference-count":35,"publisher":"Korean Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2024,8,31]]},"abstract":"<jats:p>Background: To identify a screening tool for obstructive sleep apnea (OSA) and evaluate the effects of endoscopic transsphenoidal surgery on improving OSA in patients with acromegaly.Methods: We prospectively enrolled adults with acromegaly scheduled for endoscopic transsphenoidal surgery. All measurements were conducted when participants were admitted for a baseline work-up for acromegaly before surgery and surveillance approximately 3 to 6 months after surgery. Respiratory event index (REI) was used as a surrogate for apnea-hypopnea index (Trial Registration: NCT03526016).Results: Of the 35 patients with acromegaly (median age, 47 years; 40% men; median body mass index, 24.4 kg\/m&lt;sup&gt;2&lt;\/sup&gt;), 24 (68.6%) had OSA (REI \u22655\/hour), 15 (42.9%) had moderate-to-severe OSA (REI \u226515\/hour). At baseline, serum insulin-like growth factor 1 (IGF-1) levels were positively correlated with the REI (\u03c1=0.53, &lt;i&gt;P&lt;\/i&gt;=0.001). The sensitivity and negative predictive value of a Snoring, Tiredness, Observed apnea, high blood Pressure-Body mass index, age, Neck circumference, and Gender (STOP-Bang) score \u2265 3 were 93.3% and 87.5%, respectively, detecting moderate-to-severe OSA. Biochemical acromegaly remission was achieved in 32 (91.4%) patients. The median difference in the REI was \u20139.5\/hour (95% confidence interval, \u201313.3 to \u20135.3). Half of the 24 patients diagnosed with OSA preoperatively had REI &lt;5\/hour postoperatively. In a linear mixed-effects model, changes in the REI across surgery were related to changes in IGF-1 levels.Conclusion: The STOP-Bang questionnaire is a reliable tool for OSA among patients with acromegaly. Improvement in OSA severity after surgery is related to decreased IGF-1 levels.<\/jats:p>","DOI":"10.3803\/enm.2024.1933","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T04:47:15Z","timestamp":1719377235000},"page":"641-652","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Obstructive Sleep Apnea Screening and Effects of Surgery in Acromegaly: A Prospective Study"],"prefix":"10.3803","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6537-8843","authenticated-orcid":true,"given":"Jaeyoung","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-0234","authenticated-orcid":true,"given":"Jung Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong 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