{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:25:59Z","timestamp":1792135559009,"version":"4.4.0"},"reference-count":26,"publisher":"Korean Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Queen Savang Vadhana Memorial Hospital"}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2024,10,31]]},"abstract":"<jats:p>Background: Previous studies of fixed-dose radioiodine therapy (RIT) for Graves\u2019 disease (GD) have utilized a variety of techniques and reported differing success rates. This study sought to compare the efficacy of RIT using two fixed-dose protocols and to estimate the optimal radioiodine (RAI) activity for the treatment of GD.Methods: This retrospective trial enrolled 658 patients with GD who received RIT between January 2014 and December 2021. Participants were divided into two groups: protocol 1, which utilized a thyroid size-specific RAI dose, and protocol 2, which employed a modified dose calculation approach. The primary outcome assessed was the presence of euthyroidism or hypothyroidism at the 6-month follow-up. The success rates of RIT were compared between the two protocols.Results: The RIT success rate was marginally lower for protocol 2 than for protocol 1 (63.6% vs. 67.2%); however, the risk of treatment failure did not differ considerably between the groups (relative risk, 1.1089; 95% confidence interval, 0.8937 to 1.3758; P=0.3477). The median RAI activity associated with protocol 2 was lower than that for protocol 1 (10.7 mCi vs. 15.0 mCi, P=0.0079), and the frequency of hypothyroidism was significantly lower in the protocol 2 group (39.0% vs. 48.9%, P=0.0117).Conclusion: The success rate of the modified dose calculation protocol was comparable to that of the thyroid size-specific RAI dose protocol. The former approach reduced RAI activity and the incidence of hypothyroidism following RIT without compromising the success rate.<\/jats:p>","DOI":"10.3803\/enm.2024.1950","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T07:57:39Z","timestamp":1728892659000},"page":"758-766","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of Thyroid Size-Specific Radioiodine Dose and New Modified Dose Calculation in the Treatment of Graves\u2019 Disease"],"prefix":"10.3803","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0067-1045","authenticated-orcid":true,"given":"Alisara","family":"Wongsuttilert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchirek","family":"Thamcharoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoswanich","family":"Maiprasert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4538-6296","authenticated-orcid":true,"given":"Sathapakorn","family":"Siriwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2119","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000490384"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0229"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2013.04.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0343"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530\/eje-16-0527"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03193-7"},{"key":"ref7","first-page":"241","volume-title":"A randomized controlled trial to evaluate the effectiveness of 2 regimens of fixed iodine (\u00b9\u00b3\u00b9I) doses for Graves disease treatment","author":"Santos","year":"2012"},{"key":"ref8","first-page":"900","volume-title":"Response rate and factors affecting the outcome of a fixed dose of RAI131 therapy in Graves\u2019 disease: a 10-year Egyptian experience","author":"El-Kareem","year":"2014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/mnm.0000000000000285"},{"key":"ref10","first-page":"715","volume-title":"Clinical and dosimetric variables related to outcome after treatment of Graves\u2019 disease with 550 and 1110 MBq of 131I: results of a prospective randomized trial","author":"Sapienza","year":"2015"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/0972-3919.164062"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-018-0322-7"},{"key":"ref13","first-page":"108","volume-title":"Success rate of radioactive iodine therapy in Graves\u2019 disease using dose corrected for thyroid gland size","author":"Kiatkittikul","year":"2021"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.243170"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.11152\/mu-980"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12222"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3803\/enm.2016.31.2.213"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06274-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14340"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.19080\/jpcr.2018.05.555669"},{"key":"ref21","first-page":"756","volume-title":"Clinical outcomes 1 year after empiric 131I therapy for hyperthyroid disorders: real life experience and predictive factors of functional response","author":"Vija Racaru","year":"2017"},{"key":"ref22","first-page":"1815","volume-title":"Four- to twenty-four-hour uptake ratio: an index of rapid iodine-131 turnover in hyperthyroidism","author":"Aktay","year":"1996"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08475-z"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s13139-020-00674-3"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226495"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad083"}],"container-title":["Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2024-1950.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2024.1950","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2024-1950.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T08:00:26Z","timestamp":1729843226000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2024.1950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"URL":"https:\/\/doi.org\/10.3803\/enm.2024.1950","relation":{},"ISSN":["2093-596X","2093-5978"],"issn-type":[{"value":"2093-596X","type":"print"},{"value":"2093-5978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]},"assertion":[{"value":"2024-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}