{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:55:09Z","timestamp":1775040909545,"version":"3.50.1"},"reference-count":14,"publisher":"Korean Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2024,12,31]]},"abstract":"<jats:p>Liquid chromatography-tandem mass spectrometry (LC-MS\/MS) accurately measures plasma aldosterone concentration (PAC), but its correlation with radioimmunoassay (RIA), equivalent RIA levels, and optimal cutoff for PAC and aldosterone-to-renin ratio (ARR) in primary aldosteronism (PA) screening have not been determined in a Korean population. Our study of 127 patients who underwent diagnostic testing for PA showed that the LC-MS\/MS and RIA methods have good correlation, with a mean bias of 29.3% for PAC. An LC-MS\/MS PAC level of 11.7 ng\/dL was equivalent to an RIA PAC level of 15 ng\/dL. Receiver operating characteristic curve analysis showed that an LC-MS\/MS PAC level of 10.3 ng\/dL and LC-MS\/MS ARR level of 20.0 provided sensitivity of 73.1% with a specificity of 57.3% and sensitivity of 92.3% with a specificity of 14.7%, respectively. When the LC-MS\/MS method is used for PA screening, an adjustment of cutoff values is necessary.<\/jats:p>","DOI":"10.3803\/enm.2024.1985","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T07:37:47Z","timestamp":1731656267000},"page":"965-969","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative Analysis of Liquid Chromatography-Tandem Mass Spectrometry and Radioimmunoassay in Determining Plasma Aldosterone Concentration and Plasma Renin Activity for Primary Aldosteronism Screening"],"prefix":"10.3803","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-6612","authenticated-orcid":true,"given":"So Yoon","family":"Kwon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeong-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Youn","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5001-963X","authenticated-orcid":true,"given":"Jae Hyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2119","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(17)30319-4"},{"key":"ref2","first-page":"e15985","volume-title":"Cardiovascular risk in primary aldosteronism: a systematic review and meta-analysis","author":"Wu","year":"2019"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-00948-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1032070"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.116004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3803\/enm.2023.1789"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3803\/enm.2023.1779"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01394"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3803\/enm.2022.1535"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2015-0065"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01041"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz150"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0000000000000880"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab348"}],"container-title":["Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2024-1985.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2024.1985","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-enm.org\/upload\/pdf\/enm-2024-1985.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T23:55:15Z","timestamp":1735257315000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-enm.org\/journal\/view.php?doi=10.3803\/EnM.2024.1985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,31]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"URL":"https:\/\/doi.org\/10.3803\/enm.2024.1985","relation":{},"ISSN":["2093-596X","2093-5978"],"issn-type":[{"value":"2093-596X","type":"print"},{"value":"2093-5978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,31]]},"assertion":[{"value":"2024-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-15","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}