{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:37:44Z","timestamp":1790703464914,"version":"4.1.0"},"reference-count":47,"publisher":"Korean Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009624","name":"Yonsei University College of Dentistry","doi-asserted-by":"publisher","award":["6-2018-0030"],"award-info":[{"award-number":["6-2018-0030"]}],"id":[{"id":"10.13039\/501100009624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009624","name":"Yonsei University College of Dentistry","doi-asserted-by":"publisher","award":["6-2019-0019"],"award-info":[{"award-number":["6-2019-0019"]}],"id":[{"id":"10.13039\/501100009624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2024,10,31]]},"abstract":"<jats:p>Background: Phosphatidylinositol 3-kinase (PI3K) regulates cellular development and energy homeostasis. However, the roles of its subunits in organ development remain largely unknown.Methods: We explored the roles of PI3K catalytic subunits in steroidogenic factor 1 (SF1)-expressing cells through knockout (KO) of the p110\u03b1 and p110\u03b2 subunits.Results: We examined mice with a double KO of p110\u03b1 and p110\u03b2 in SF1-expressing cells (p110\u03b1\u03b2 KOSF1). Although these animals exhibited no significant changes in the development of the ventromedial hypothalamus, we noted pronounced hypotrophy in the adrenal cortex, testis, and ovary. Additionally, corticosterone and aldosterone levels were significantly reduced. The absence of these subunits also resulted in decreased body weight and survival rate, along with impaired glucose homeostasis, in p110\u03b1\u03b2 KOSF1 mice.Conclusion: The data demonstrate the specific roles of PI3K catalytic subunits in the development and function of SF1-expressing organs.<\/jats:p>","DOI":"10.3803\/enm.2024.1999","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T08:58:51Z","timestamp":1725008331000},"page":"793-802","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Subunit-Specific Developmental Roles of PI3K in SF1-Expressing Cells"],"prefix":"10.3803","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8002-881X","authenticated-orcid":true,"given":"My Khanh 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