{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:27:41Z","timestamp":1782199661749,"version":"3.54.5"},"reference-count":29,"publisher":"Korean Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00262002"],"award-info":[{"award-number":["RS-2023-00262002"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["e-enm.org"],"crossmark-restriction":true},"short-container-title":["Endocrinol Metab"],"published-print":{"date-parts":[[2025,4,30]]},"abstract":"<jats:p>Background: We aimed to investigate the predictive values of plasma C-peptide levels and the continuous glucose monitoring (CGM)-defined coefficient of variation (CV) in risk prediction for hypoglycemia in Korean people with diabetes with normal and impaired kidney function.Methods: We analyzed data from 1,185 participants diagnosed with type 1 and type 2 diabetes who underwent blinded professional CGM between January 2009 and May 2021 at outpatient clinics. We explored correlations among CGM-defined CV, plasma C-peptide levels, and time below range at &lt;70 and 54 mg\/dL across different kidney function categories.Results: In patients with chronic kidney disease (CKD) stages 1\u20132 (n=934), 89.3% who had a random plasma C-peptide level higher than 600 pmol\/L exhibited a CV of \u226436%. Among those in CKD stage 3 (n=161) with a random plasma C-peptide level exceeding 600 pmol\/L, 66.7% showed a CV of \u226436%. In stages 4\u20135 of CKD (n=90), the correlation between random C-peptide levels and CV was not significant (r=\u20130.05, P=0.640), including cases with a CV greater than 36% despite very high random plasma C-peptide levels. Random plasma C-peptide levels and CGM-assessed CV significantly predicted hypoglycemia in CKD stages 1\u20132 and 1\u20135, respectively.Conclusion: The established C-peptide criteria in Western populations are applicable to Korean people with diabetes for hypoglycemic risk prediction, unless kidney function is impaired equivalent to CKD stage 3\u20135. The CGM-defined CV is informative for hypoglycemic risk prediction regardless of kidney function.<\/jats:p>","DOI":"10.3803\/enm.2024.2083","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T05:40:49Z","timestamp":1740634849000},"page":"268-277","update-policy":"https:\/\/doi.org\/10.3803\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma C-Peptide Levels and the Continuous Glucose Monitoring-Defined Coefficient of Variation in Risk Prediction for Hypoglycemia in Korean People with Diabetes Having Normal and Impaired Kidney Function"],"prefix":"10.3803","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-6612","authenticated-orcid":true,"given":"So 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