{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:45:01Z","timestamp":1792586701712,"version":"4.5.0"},"reference-count":0,"publisher":"The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)","issue":"3","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food and Drug Analysis"],"abstract":"<jats:p>Plant-derived nanovesicles (PDNVs) offer a promising, biocompatible therapeutic platform. In this study, we isolatednanovesicles from protocorm-like bodies of Dendrobium of\ufb01cinale (PLBs-NVs) and evaluated their ef\ufb01cacy in dry eyedisease (DED) models. PLBs-NVs protected human corneal epithelial cells against hyperosmotic stress, supportedwound repair, and inhibited in\ufb02ammation in vitro. In a desiccating stress-induced DED mouse model, topical PLBs-NVstreatment signi\ufb01cantly restored tear secretion, reduced corneal epithelial damage, and lowered levels of proin\ufb02ammatorycytokines. These results suggest that PLBs-NVs are a safe, natural, and effective therapeutic strategy for DED, sup-porting their potential for future clinical translation in ocular surface disorders.<\/jats:p>","DOI":"10.38212\/2224-6614.3559","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:38:54Z","timestamp":1758314334000},"page":"312-324","source":"Crossref","is-referenced-by-count":0,"title":["Nanovesicles derived from protocorm-like bodies of Dendrobium of\ufb01cinal enhance corneal epithelial repair and reduce in\ufb02ammation in dry eye disease models"],"prefix":"10.38212","volume":"33","author":[{"given":"Bao","family":"Yuqing","sequence":"first","affiliation":[{"name":"Jinzhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chengyu","sequence":"additional","affiliation":[{"name":"Jinzhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Fenglei","sequence":"additional","affiliation":[{"name":"Stem Cell Center of Precision Medicine Innovation Institute, He University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yuqiang","sequence":"additional","affiliation":[{"name":"Stem Cell Center of Precision Medicine Innovation Institute, He University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Mingqi","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Center of Precision Medicine Innovation Institute, He University, No.66 Sishui Street, Hunnan District, Shenyang, 110163, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Center of Precision Medicine Innovation Institute, He University, No.66 Sishui Street, Hunnan District, Shenyang, 110163, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25385","published-online":{"date-parts":[[2025,9,17]]},"container-title":["Journal of Food and Drug Analysis"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:15:15Z","timestamp":1792584915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jfda-online.com\/journal\/vol33\/iss3\/10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,17]]}},"URL":"https:\/\/doi.org\/10.38212\/2224-6614.3559","relation":{},"ISSN":["2224-6614"],"issn-type":[{"value":"2224-6614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]}}}