{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:44:58Z","timestamp":1792586698854,"version":"4.5.0"},"reference-count":0,"publisher":"The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)","issue":"3","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food and Drug Analysis"],"abstract":"<jats:p>A series of chromatographic separation on the liquid-state fermented products of Didymocyrtis brachylaenae Km1530 derived from the littoral medicinal herb Atriplex maximowicziana Makino, resulted in the isolation of compounds 1\u201413. Their structures were determined by spectroscopic analysis as fivepreviously unreported C13 polyketides, namely brachylactones A\u2014D (1\u20144) and brachic acid (5), along with eight known compounds 6\u201413. Among these, brachy-lactones A (1) and B (2) exhibited nitric oxide production inhibitory activity in lipopolysaccharide-induced murine BV- 2 microglial cells at a concentration of 20 \u03bcM without any cytotoxicity.<\/jats:p>","DOI":"10.38212\/2224-6614.3560","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:39:00Z","timestamp":1758314340000},"page":"302-311","source":"Crossref","is-referenced-by-count":1,"title":["Anti-neuroinflammatory polyketides from the medicinal herb-derived fungal strain Didymocyrtis brachylaenae Km1530"],"prefix":"10.38212","volume":"33","author":[{"given":"Chia-Hao","family":"Chang","sequence":"first","affiliation":[{"name":"Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Jung","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chiung","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Food Science, National Quemoy University, Kinmen 89250, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gu","sequence":"additional","affiliation":[{"name":"Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wei","family":"Lai","sequence":"additional","affiliation":[{"name":"Center of General Education, National Taipei University, New Taipei 273303, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Huei","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Fisheries Science, College of Life Science, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25385","published-online":{"date-parts":[[2025,9,17]]},"container-title":["Journal of Food and Drug Analysis"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:15:14Z","timestamp":1792584914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jfda-online.com\/journal\/vol33\/iss3\/9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,17]]}},"URL":"https:\/\/doi.org\/10.38212\/2224-6614.3560","relation":{},"ISSN":["2224-6614"],"issn-type":[{"value":"2224-6614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]}}}