{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:44:44Z","timestamp":1792586684224,"version":"4.5.0"},"reference-count":0,"publisher":"The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)","issue":"3","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food and Drug Analysis"],"abstract":"<jats:p>Atopic dermatitis (AD) is a chronic inflammatory disease characterized by recurrent bacterial infections that cause pruritus, erythema, xerosis and thickening. Cajanus cajan root extract prepared with 95% ethanol (EECR95) has been shown to possess antioxidant, anti-inflammatory, and antibacterial properties in previous studies. This study aimed to evaluate EECR95\u2019s ability to improve AD by inhibiting methicillin-resistant Staphylococcus aureus (MRSA) growth and reducing inflammation. This study found EECR95 effectively inhibits MRSA growth (IC50 = 103.74 \u03bcg\/mL) and reduces pro-inflammatory cytokine production in an MRSA-keratinocyte-macrophage model. LC\/MS\/MS analysis revealed the presence of active compounds- flavonoids, isoflavones, and flavonoid glycosides, highlighting EECR95's potential in improving atopic dermatitis in vitro.<\/jats:p>","DOI":"10.38212\/2224-6614.3591","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T15:37:31Z","timestamp":1786894651000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Potential of Cajanus cajan (L.) Millsp. Root to Improve Atopic Dermatitis with Different Anti-inflammatory Models and Active Compounds"],"prefix":"10.38212","volume":"34","author":[{"given":"Shu-Er","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Beauty Science and Master Program of Beauty Science and Technology,\u00a0Chienkuo Technology University, Changhua, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ming","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Taichung Veterans General Hospital, Taichung, Taiwan (R.O.C);"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Chieh","family":"Tsai","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Medical University, Taichung, Taiwan No. 100, Section 1, Jingmao Road, Beitun District, Taichung City 406040Affiliation 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mey-Fann","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan (R.O.C);"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuzz-Ying","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25385","published-online":{"date-parts":[[2026,8,11]]},"container-title":["Journal of Food and Drug Analysis"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:14:13Z","timestamp":1792584853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jfda-online.com\/journal\/vol34\/iss3\/12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,8,11]]}},"URL":"https:\/\/doi.org\/10.38212\/2224-6614.3591","relation":{},"ISSN":["2224-6614"],"issn-type":[{"value":"2224-6614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]}}}