{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:31:07Z","timestamp":1793961067341,"version":"4.8.0"},"reference-count":0,"publisher":"The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)","issue":"3","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Food and Drug Analysis"],"abstract":"<jats:p>Garambullo (Myrtillocactus geometrizans) is a Mexican fruit rich in bioactive phytochemicals. Its fermented extract (FEG), obtained after in vitro gastrointestinal digestion and fermentation, was evaluated in HT-29 and SW480 colorectal cancer cells. FEG reduced cell viability (IC50: 2985 and 3200 \u03bcg\/mL, respectively) and induced apoptosis and necrosis. In 3D assays, FEG inhibited colony formation, with complete suppression in HT-29 cells. Molecular docking further suggested that butyric acid identified in FEG interacts with Caspase-3 and RIPK1. These findings support the antiproliferative and pro-death effects of FEG in colorectal cancer models.<\/jats:p>","DOI":"10.38212\/2224-6614.3599","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T08:15:14Z","timestamp":1785744914000},"source":"Crossref","is-referenced-by-count":0,"title":["Garambullo (Myrtillocactus geometrizans) Reduces Cell Viability via Apoptosis and Inhibits Colony Formation in HT-29 and SW480 Colon Cancer Cell Lines."],"prefix":"10.38212","volume":"34","author":[{"given":"L\u00f3pez-Alvarez Guadalupe","family":"Soledad","sequence":"first","affiliation":[{"name":"Center for Advanced Biomedical Research, Faculty of Medicine, Autonomous University of Queretaro. Santiago de Quer\u00e9taro 76140, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gutierrez-Silerio Gloria","family":"Yareli","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomedical Research, Faculty of Medicine, Autonomous University of Queretaro. Santiago de Quer\u00e9taro 76140, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garc\u00eda-Sol\u00eds","family":"Pablo","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomedical Research, Faculty of Medicine, Autonomous University of Queretaro. Santiago de Quer\u00e9taro 76140, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morales-B\u00e1rcenas","family":"Rocio","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda. Mexico City, 14080, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1nchez-P\u00e9rez","family":"Yesennia","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda. Mexico City, 14080, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1ndez-Puga Ana","family":"Gabriela","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomedical Research, Faculty of Medicine, Autonomous University of Queretaro. Santiago de Quer\u00e9taro 76140, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vergara-Casta\u00f1eda Hayd\u00e9","family":"Azeneth","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomedical Research, Faculty of Medicine, Autonomous University of Queretaro. Santiago de Quer\u00e9taro 76140, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"25385","published-online":{"date-parts":[[2026,7,30]]},"container-title":["Journal of Food and Drug Analysis"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:14:23Z","timestamp":1793960063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jfda-online.com\/journal\/vol34\/iss3\/8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,7,30]]}},"URL":"https:\/\/doi.org\/10.38212\/2224-6614.3599","relation":{},"ISSN":["2224-6614"],"issn-type":[{"value":"2224-6614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}