{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:35:34Z","timestamp":1783686934828,"version":"3.55.0"},"reference-count":43,"publisher":"Korean Pharmacopuncture Institute","issue":"1","funder":[{"name":"Korea Federation of Science and Technology Societies(KOFST)"}],"content-domain":{"domain":["www.journal.ac"],"crossmark-restriction":true},"short-container-title":["J. Pharmacopunct"],"published-print":{"date-parts":[[2017,3,31]]},"DOI":"10.3831\/kpi.2017.20.001","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T01:00:18Z","timestamp":1490835618000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.3831\/kpi.crossmark.policy","source":"Crossref","is-referenced-by-count":53,"title":["Boswellic Acid Improves Cognitive Function in a Rat Model Through Its Antioxidant Activity"],"prefix":"10.3831","volume":"20","author":[{"given":"Hossein","family":"Hosseinzadeh","sequence":"first","affiliation":[{"name":"2 Department of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh","family":"Ebrahimpour","sequence":"additional","affiliation":[{"name":"1 Department of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Fazeli","sequence":"additional","affiliation":[{"name":"1 Department of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soghra","family":"Mehri","sequence":"additional","affiliation":[{"name":"2 Department of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Taherianfard","sequence":"additional","affiliation":[{"name":"3 Department of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2168","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"issue":"3","key":"key20170330094646_B001","first-page":"237","article-title":"Pathogenesis of trimethyltin neuronal toxicity. ultrastructural and cytochemical observations","volume":"104","author":"Bouldin","year":"1981","journal-title":"Am J Pathol"},{"issue":"2","key":"key20170330094646_B002","first-page":"127","article-title":"The trimethyltin syndrome in rats","volume":"4","author":"Dyer","year":"1982","journal-title":"Neurobehav Toxicol Teratol"},{"issue":"1","key":"key20170330094646_B003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00377794","article-title":"Trimethyltin poisoning. report of two cases","volume":"41","author":"Fortemps","year":"1978","journal-title":"Int Arch Occup Environ Health"},{"issue":"1","key":"key20170330094646_B004","first-page":"59","article-title":"The behavioral and neuropathologic sequelae of intoxication by trimethyltin compounds in the rat","volume":"97","author":"Brown","year":"1979","journal-title":"Am J Pathol"},{"issue":"3","key":"key20170330094646_B005","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.neuroscience.2005.02.030","article-title":"Ascorbate attenuates trimethyltin-induced oxidative burden and neuronal degeneration in the rat hippocampus by maintaining glutathione homeostasis","volume":"133","author":"Shin","year":"2005","journal-title":"Neuroscience"},{"issue":"4-5","key":"key20170330094646_B006","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.neuint.2007.09.003","article-title":"In vivo depletion of endogenous glutathione facilitates trimethyltin-induced neuronal damage in the dentate gyrus of mice by enhancing oxidative stress","volume":"52","author":"Yoneyama","year":"2008","journal-title":"Neurochem Int"},{"issue":"2","key":"key20170330094646_B007","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.phymed.2012.10.003","article-title":"Ginkgo biloba extract attenuates hippocampal neuronal loss and cognitive dysfunction resulting from trimethyltin in mice","volume":"20","author":"Kaur","year":"2013","journal-title":"Phytomedicine"},{"issue":"5","key":"key20170330094646_B008","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0009-9120(94)00039-5","article-title":"Role of chemopreventers in human diet","volume":"27","author":"Stavric","year":"1994","journal-title":"Clin Biochem"},{"issue":"3","key":"key20170330094646_B009","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ptr.3566","article-title":"Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats","volume":"26","author":"Hosseinzadeh","year":"2012","journal-title":"Phytother Res"},{"issue":"12","key":"key20170330094646_B010","first-page":"51","article-title":"Effects of Rosmarinus officinalis L. aerial parts essential oil on intact memory and scopolamine-induced learning deficits in rats performing the morris water maze task","volume":"4","author":"Hosseinzadeh","year":"2004","journal-title":"J Medicinal Plants"},{"issue":"1","key":"key20170330094646_B011","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0361-090X(02)00170-8","article-title":"Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells","volume":"27","author":"Zhao","year":"2003","journal-title":"Cancer Detect Prev"},{"issue":"28","key":"key20170330094646_B012","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.2174\/092986706779010333","article-title":"Boswellic acids: biological actions and molecular targets","volume":"13","author":"Poeckel","year":"2006","journal-title":"Curr Med Chem"},{"issue":"12","key":"key20170330094646_B013","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1055\/s-2006-947227","article-title":"Boswellic acids in chronic inflammatory diseases","volume":"72","author":"Ammon","year":"2006","journal-title":"Planta Med"},{"issue":"12","key":"key20170330094646_B014","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1002\/ptr.5701","article-title":"Aqueous and ethanolic extracts of Boswellia serrata protect against focal cerebral ischemia and reperfusion injury in rats","volume":"30","author":"Forouzanfar","year":"2016","journal-title":"Phytother Res"},{"issue":"34","key":"key20170330094646_B015","first-page":"95","article-title":"Effects Boswellia carterii gum resin fractions on intact memory and hyoscine-induced learning impairments in rats performing the morris water maze task","volume":"2","author":"Hosseinzadeh","year":"2010","journal-title":"J Med Plants"},{"issue":"4","key":"key20170330094646_B016","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.foodchem.2004.08.033","article-title":"Antioxidant activity of natural resins and bioactive triterpenes in oil substrates","volume":"92","author":"Assimopoulou","year":"2005","journal-title":"Food Chem"},{"issue":"8","key":"key20170330094646_B017","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1007\/s10620-012-2134-3","article-title":"Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid","volume":"57","author":"Hartmann","year":"2012","journal-title":"Dig Dis Sci"},{"issue":"1","key":"key20170330094646_B018","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.foodchem.2012.07.084","article-title":"Phytochemical composition and in vitro antimicrobial and antioxidant activities of some medicinal plants","volume":"136","author":"Jaberian","year":"2013","journal-title":"Food Chem"},{"issue":"2","key":"key20170330094646_B019","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S2221-1691(11)60206-2","article-title":"Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti- oxidant status in gouty arthritic mice","volume":"2","author":"Sabina","year":"2012","journal-title":"Asian Pac J Trop Biomed"},{"issue":"2","key":"key20170330094646_B020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4062\/biomolther.2012.20.2.207","article-title":"Krill-derived phosphatidylserine improves TMT-induced memory impairment in the rat","volume":"20","author":"Shim","year":"2012","journal-title":"Biomol Ther"},{"issue":"1","key":"key20170330094646_B021","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J Neurosci Methods"},{"issue":"1","key":"key20170330094646_B022","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Mihara","year":"1978","journal-title":"Anal Biochem"},{"issue":"1","key":"key20170330094646_B023","first-page":"64","article-title":"Crocin restores hypotensive effect of subchronic administration of diazinon in rats","volume":"16","author":"Razavi","year":"2013","journal-title":"Iran J Basic Med Sci"},{"issue":"3","key":"key20170330094646_B024","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/taap.1999.8845","article-title":"Trimethyltin and triethyltin differentially induce spontaneous noradrenaline release from rat hippocampal slices","volume":"162","author":"Gasso","year":"2000","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"key20170330094646_B025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.toxlet.2003.10.023","article-title":"The neurotoxicant trimethyltin induces apoptosis via caspase activation, p38 protein kinase, and oxidative stress in PC12 cells","volume":"147","author":"Jenkins","year":"2004","journal-title":"Toxicol lett"},{"issue":"3","key":"key20170330094646_B026","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0022-3565(25)12398-7","article-title":"Induction of apoptosis by organotin compounds in vitro: neuronal protection with antisense oligonucleotides directed against stannin","volume":"276","author":"Thompson","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"issue":"10","key":"key20170330094646_B027","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1271\/bbb.110386","article-title":"Effects of methoxsalen from Poncirus trifoliata on acetylcholinesterase and trimethyltin-induced learning and memory impairment","volume":"75","author":"Kim","year":"2011","journal-title":"Biosci Biotechnol Biochem"},{"issue":"4","key":"key20170330094646_B028","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1023\/A:1007667830022","article-title":"Differential gliotoxicity of organotins","volume":"15","author":"Karpiak","year":"1999","journal-title":"Cell Biol Toxicol"},{"issue":"4","key":"key20170330094646_B029","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s002040050488","article-title":"Glutathione modifies the toxicity of triethyltin and trimethyltin in C6 glioma cells","volume":"72","author":"Cookson","year":"1998","journal-title":"Arch Toxicol"},{"issue":"5","key":"key20170330094646_B030","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/jbt.10004","article-title":"Role of astrocytes in trimethyltin neurotoxicity","volume":"15","author":"Gunasekar","year":"2001","journal-title":"J Biochem Mol Toxicol"},{"key":"key20170330094646_B031","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.neuint.2011.10.005","article-title":"Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway","volume":"59)8)","author":"Qu","year":"2011","journal-title":"Neurochem Int"},{"issue":"2","key":"key20170330094646_B032","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.foodchem.2011.11.089","article-title":"Effect of quercetin on learning and memory performance in ICR mice under neurotoxic trimethyltin exposure","volume":"132","author":"Choi","year":"2012","journal-title":"Food Chem"},{"issue":"1-2","key":"key20170330094646_B033","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neulet.2005.01.031","article-title":"Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease","volume":"380","author":"Bohnen","year":"2005","journal-title":"Neurosci Lett"},{"issue":"1","key":"key20170330094646_B034","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1196\/annals.1317.060","article-title":"Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice","volume":"1070","author":"Morita","year":"2006","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"key20170330094646_B035","first-page":"349","article-title":"The use of an unbaited tunnel maze in neurotoxicology: I. trimethyltin-induced brain lesions","volume":"15","author":"Alessandri","year":"1993","journal-title":"Neurotoxicology"},{"issue":"2","key":"key20170330094646_B036","first-page":"169","article-title":"Impaired maze performance in the rat caused by trimethyltin treatment: problem-solving deficits and perseveration","volume":"4","author":"Swartzwelder","year":"1982","journal-title":"Neurobehavioral Toxicology & Teratology"},{"issue":"1","key":"key20170330094646_B037","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0306-4522(88)90150-9","article-title":"Trimethyltin- induced neuronal damage in the rat brain: comparative studies using silver degeneration stains, immunocytochemistry and immunoassay for neuronotypic and gliotypic proteins","volume":"26","author":"Balaban","year":"1988","journal-title":"Neuroscience"},{"issue":"6","key":"key20170330094646_B038","first-page":"673","article-title":"Trimethyltin induced pathology in sensory neurons","volume":"5","author":"Chang","year":"1983","journal-title":"Neurobeh Toxicol Teratol"},{"issue":"2","key":"key20170330094646_B039","doi-asserted-by":"crossref","first-page":"587","DOI":"10.55782\/ane-1996-1164","article-title":"How does trimethyltin affect the brain: facts and hypotheses","volume":"56","author":"Koczyk","year":"1995","journal-title":"Acta Neurobiol Exp"},{"issue":"3","key":"key20170330094646_B040","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0197-0186(92)90186-U","article-title":"Behavioural, biochemical and histological effects of trimethyltin (TMT) induced brain damage in the rat","volume":"21","author":"Earley","year":"1992","journal-title":"Neurochem Int"},{"issue":"1","key":"key20170330094646_B041","first-page":"53","article-title":"Selective behavioural impairment after acute intoxication with trimethyltin (TMT) in rats","volume":"9","author":"Hagan","year":"1987","journal-title":"Neurotoxicology"},{"issue":"2","key":"key20170330094646_B042","first-page":"177","article-title":"Trimethyltin, a selective limbic system neurotoxicant, impairs radial-arm maze performance","volume":"4","author":"Walsh","year":"1982","journal-title":"Neurobeh Toxicol Teratol"},{"issue":"6","key":"key20170330094646_B043","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0031-9384(94)90387-5","article-title":"Effects of trimethyltin on acquisition and reversal of a light-dark discrimination by rats","volume":"55","author":"Woodruff","year":"1994","journal-title":"Physiol Behav"}],"container-title":["Journal of Pharmacopuncture"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T19:23:51Z","timestamp":1750188231000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.journal.ac\/article\/20\/1\/10"}},"subtitle":["- Neuroprotective effect of Boswellic acid -"],"short-title":[],"issued":{"date-parts":[[2017,3,31]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,3,31]]},"published-print":{"date-parts":[[2017,3,31]]}},"alternative-id":["10.3831\/KPI.2017.20.001"],"URL":"https:\/\/doi.org\/10.3831\/kpi.2017.20.001","relation":{},"ISSN":["2093-6966","2234-6856"],"issn-type":[{"value":"2093-6966","type":"print"},{"value":"2234-6856","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,31]]},"assertion":[{"value":"2016-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}