{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:35:45Z","timestamp":1777451745767,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Oxidant stress contributes to the pathogenesis of multiple conditions and can be assessed by measuring plasma F\n                      <jats:sub>2<\/jats:sub>\n                      -isoprostane concentrations. We hypothesized that oxidant stress is associated with plasma homocysteine concentration and risk factors for atherosclerosis in HIV-infected women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We measured plasma F\n                      <jats:sub>2<\/jats:sub>\n                      -isoprostane concentrations in a cross-sectional study of 249 HIV-infected women attending the Bronx (NY, USA) site of the Women's Interagency HIV Study and assessed associations with plasma homocysteine concentration and other metabolic parameters by linear regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In multivariate analysis, hepatitis C virus (HCV) viraemia, waist circumference, homocysteine concentration and serum aspartate aminotransferase level were positively associated with log F\n                      <jats:sub>2<\/jats:sub>\n                      -isoprostane concentration (all P&lt;0.005). There was a trend for an inverse association between log F\n                      <jats:sub>2<\/jats:sub>\n                      -isoprostane and CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell percentage ( P=0.06). Among women with HCV infection, the FIB-4 index, an indirect marker of liver fibrosis derived from routine laboratory tests, was positively associated with log F\n                      <jats:sub>2<\/jats:sub>\n                      -isoprostane concentration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this cross-sectional study of HIV-infected women, plasma F\n                      <jats:sub>2<\/jats:sub>\n                      -isoprostane concentration was positively associated with homocysteine concentration, as well as HCV infection, abdominal obesity and aspartate aminotransferase level.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp1290","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T13:58:45Z","timestamp":1254751125000},"page":"763-769","source":"Crossref","is-referenced-by-count":10,"title":["Oxidant stress in HIV-infected women from the Women's Interagency HIV Study"],"prefix":"10.1177","volume":"14","author":[{"given":"Marshall J","family":"Glesby","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald R","family":"Hoover","sequence":"additional","affiliation":[{"name":"Department of Statistics and Biostatistics, Rutgers University, Piscataway, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farbod","family":"Raiszadeh","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Luke's-Roosevelt Hospital Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Lee","sequence":"additional","affiliation":[{"name":"Data Solutions, LLC, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuhu","family":"Shi","sequence":"additional","affiliation":[{"name":"Data Solutions, LLC, Bronx, NY, USA"},{"name":"School of Public Health, New York Medical College, Valhalla, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginger","family":"Milne","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie C","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montefore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Montefore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D","family":"Morrow","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Anastos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Montefore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,8,1]]},"reference":[{"key":"bibr1-IMP1290","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000152605.64964.c0"},{"key":"bibr2-IMP1290","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.10.056"},{"key":"bibr3-IMP1290","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.44.101802.121851"},{"key":"bibr4-IMP1290","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0817"},{"key":"bibr5-IMP1290","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.001"},{"key":"bibr6-IMP1290","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(07)33006-1"},{"key":"bibr7-IMP1290","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200309010-00006"},{"key":"bibr8-IMP1290","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000226792.16216.1c"},{"key":"bibr9-IMP1290","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.037630"},{"key":"bibr10-IMP1290","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.547"},{"key":"bibr11-IMP1290","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.5.1263"},{"key":"bibr12-IMP1290","doi-asserted-by":"publisher","DOI":"10.2174\/1389200052997357"},{"key":"bibr13-IMP1290","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199803000-00004"},{"key":"bibr14-IMP1290","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"bibr15-IMP1290","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f22cdf"},{"key":"bibr16-IMP1290","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"bibr17-IMP1290","doi-asserted-by":"publisher","DOI":"10.1086\/379776"},{"key":"bibr18-IMP1290","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf029"},{"key":"bibr19-IMP1290","unstructured":"Dageforde L.A., Shintani A., Haas D. NNRTI use may be associated with decreased oxidant stress during HIV therapy.\n                      14th Conference on Retroviruses and Opportunistic Infections.\n                      25\u201328 February 2007, Los Angeles, CA, USA. Abstract 798."},{"key":"bibr20-IMP1290","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"bibr21-IMP1290","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055227"},{"key":"bibr22-IMP1290","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0084"},{"key":"bibr23-IMP1290","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07339-7"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:49:04Z","timestamp":1777380544000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP1290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,1]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.3851\/IMP1290"],"URL":"https:\/\/doi.org\/10.3851\/imp1290","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,1]]}}}