{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:49:39Z","timestamp":1759063779999},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antivir Chem Chemother"],"published-print":{"date-parts":[[2010,2]]},"abstract":"Background:<\/jats:title> The development of antiviral drugs has provided crucial new means to mitigate or relieve the debilitating effects of many viral pathogens. New classes of inhibitors are essential to combat swine influenza viral infection. <\/jats:p><\/jats:sec>Methods:<\/jats:title> A series of isatine-sulfadimidine derivatives were screened for antiviral activity against swine influenza A\/California\/07\/2009 (H1N1) virus in Madin\u2013Darby canine kidney (MDCK) cell culture. Cytotoxicity of the synthesized compounds was also tested in uninfected MDCK cells. <\/jats:p><\/jats:sec>Results:<\/jats:title> All the compounds inhibit the influenza A (H1N1) in MDCK cells. The most active compounds, SPIII-5Br and SPIII-5H, inhibited virus-induced cytopathology by 50% at 27 and 30 \u03bcM, respectively, with 50% cytotoxicity occurring at a much higher dose (975\u20131,000 \u03bcM). The positive control compound ribavirin inhibits the replication of the virus at 18 \u03bcM and cytotoxic concentration was found to be >1,000 \u03bcM. <\/jats:p><\/jats:sec>Conclusions:<\/jats:title> SPIII-5Br and SPIII-5H exhibited potency in the same range as ribavirin and are suitable candidate molecules for further investigation. <\/jats:p><\/jats:sec>","DOI":"10.3851\/imp1471","type":"journal-article","created":{"date-parts":[[2009,12,16]],"date-time":"2009-12-16T15:46:14Z","timestamp":1260978374000},"page":"143-146","source":"Crossref","is-referenced-by-count":7,"title":["Activity of Isatine-Sulfadimidine Derivatives against 2009 Pandemic H1N1 Influenza Virus in Cell Culture"],"prefix":"10.1177","volume":"20","author":[{"given":"Periyasamy","family":"Selvam","sequence":"first","affiliation":[{"name":"Devaki Amma Memorial College of Pharmacy, Chelembra, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markandavel","family":"Chandramohan","sequence":"additional","affiliation":[{"name":"Bharat Ratna Kamarajar Liver Hospital and Research Centre, Madurai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett L","family":"Hurst","sequence":"additional","affiliation":[{"name":"Institute for Antiviral Research, Utah State University, Logan, UT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald F","family":"Smee","sequence":"additional","affiliation":[{"name":"Institute for Antiviral Research, Utah State University, Logan, UT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"bibr1-IMP1471","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-129"},{"key":"bibr2-IMP1471","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903810"},{"key":"bibr3-IMP1471","doi-asserted-by":"publisher","DOI":"10.1099\/vir.2008.007260-0"},{"key":"bibr4-IMP1471","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.06.016"},{"key":"bibr5-IMP1471","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2698"},{"key":"bibr6-IMP1471","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1960.tb01216.x"},{"key":"bibr7-IMP1471","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121340"},{"key":"bibr8-IMP1471","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.02.010"},{"key":"bibr9-IMP1471","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-46-1-195"},{"key":"bibr10-IMP1471","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(94)90077-9"},{"key":"bibr11-IMP1471","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(01)00197-X"},{"key":"bibr12-IMP1471","first-page":"465","volume":"66","author":"Selvam P","year":"2004","journal-title":"Indian J Pharm Sci"},{"key":"bibr13-IMP1471","doi-asserted-by":"publisher","DOI":"10.1177\/095632020601700206"},{"key":"bibr14-IMP1471","doi-asserted-by":"publisher","DOI":"10.1177\/095632020601700504"},{"key":"bibr15-IMP1471","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.743-748.2001"},{"key":"bibr16-IMP1471","first-page":"493","volume":"27","author":"Reed LJ","year":"1938","journal-title":"Am J Hyg"},{"key":"bibr17-IMP1471","doi-asserted-by":"publisher","DOI":"10.1177\/095632020701800506"}],"container-title":["Antiviral Chemistry and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3851\/IMP1471","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T20:23:35Z","timestamp":1725654215000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP1471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,1]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.3851\/IMP1471"],"URL":"https:\/\/doi.org\/10.3851\/imp1471","relation":{},"ISSN":["0956-3202","2040-2066"],"issn-type":[{"type":"print","value":"0956-3202"},{"type":"electronic","value":"2040-2066"}],"subject":[],"published":{"date-parts":[[2010,1,1]]}}}