{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:18:07Z","timestamp":1790151487845,"version":"4.0.1"},"reference-count":63,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>Treatment guidelines are continuously evolving in chronic viral hepatitis, taking into consideration our greater understanding of natural history and therapeutic efficacy and safety. Key in the decision making process is an assessment of liver injury. Traditionally, liver biopsy has provided this information; however, this is an invasive procedure and not completely reliable. Liver transient elastography (Fibroscan\u00ae) is exciting new technology that allows estimation of hepatic fibrosis through measurement of liver stiffness. It is acceptably accurate, safe, cheap, quick and widely applicable, and can reduce the need for liver biopsy in chronic hepatitis. In chronic hepatitis C, it can identify those most likely to benefit from treatment, as well as those with cirrhosis who require more specific care. In chronic hepatitis B, it could screen groups previously excluded from treatment (normal alanine aminotransferase and low DNA) to identify the subgroup that would benefit from therapy. It cannot replace biopsy in all settings, but it will narrow the group who do require biopsy, and provide information on liver damage in patients for whom biopsy would probably not have been considered.<\/jats:p>","DOI":"10.3851\/imp1474","type":"journal-article","created":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T06:52:10Z","timestamp":1262760730000},"page":"1-11","source":"Crossref","is-referenced-by-count":28,"title":["Liver Transient Elastography (Fibroscan\u00ae): A Place in the Management Algorithms of Chronic Viral Hepatitis"],"prefix":"10.1177","volume":"15","author":[{"given":"David R","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Liverpool Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam T","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Liverpool Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,1,1]]},"reference":[{"key":"bibr1-IMP1474","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.084475"},{"key":"bibr2-IMP1474","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200104"},{"key":"bibr3-IMP1474","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.1999.tb00033.x"},{"key":"bibr4-IMP1474","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06038.x"},{"key":"bibr5-IMP1474","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.09022"},{"key":"bibr6-IMP1474","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.001"},{"key":"bibr7-IMP1474","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.10010"},{"key":"bibr8-IMP1474","first-page":"A248","volume":"21","author":"Wiseman E.","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"bibr9-IMP1474","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.10.014"},{"key":"bibr10-IMP1474","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01216.x"},{"key":"bibr11-IMP1474","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.16602"},{"key":"bibr12-IMP1474","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-9-200011070-00008"},{"key":"bibr13-IMP1474","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2002.tb04286.x"},{"key":"bibr14-IMP1474","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"bibr15-IMP1474","unstructured":"BioPredictive. The non-invasive tests, alternative to liver biopsy. (Accessed 31 May 2009.) 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Liver stiffness values in the normal population: a study of voluntary blood donors.\n                      59th Annual Meeting of the American Association for the Study of Liver Diseases\n                      . 31 October\u20134 November 2008, San Francisco, USA. Abstract 1550."},{"key":"bibr30-IMP1474","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.11.020"},{"key":"bibr31-IMP1474","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.10.019"},{"key":"bibr32-IMP1474","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.018"},{"key":"bibr33-IMP1474","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003857"},{"key":"bibr34-IMP1474","unstructured":"Castera L., Le Bail B., Foucher J. Prospective analysis of discordance between FibroScan and FibroTest when used in combination as first-line assessment of liver fibrosis in chronic hepatitis C.\n                      56th Annual Meeting of the American Association for the Study of Liver Diseases.\n                      11\u201315 November 2005, San Francisco, CA, USA. Abstract 619."},{"key":"bibr35-IMP1474","unstructured":"Castera L., Haaser M., Le Bail B. Prevalence and causes of discordance between Fibroscan and Fibrotest for first line assessment of liver fibrosis in chronic hepatitis C: a prospective analysis over 4 years in 3148 patients.\n                      59th Annual Meeting of the American Association for the Study of Liver Diseases\n                      . 31 October\u20134 November 2008, San Francisco, CA, USA. Abstract 1766."},{"key":"bibr36-IMP1474","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.076"},{"key":"bibr37-IMP1474","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.06.012"},{"key":"bibr38-IMP1474","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200604000-00015"},{"key":"bibr39-IMP1474","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(09)60129-X"},{"key":"bibr40-IMP1474","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22007"},{"key":"bibr41-IMP1474","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20506"},{"key":"bibr42-IMP1474","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.149708"},{"key":"bibr43-IMP1474","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.038"},{"key":"bibr44-IMP1474","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01802.x"},{"key":"bibr45-IMP1474","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02157.x"},{"key":"bibr46-IMP1474","unstructured":"Verveer C., Zondervan P.E., Janssen H.L. 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