{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:52:30Z","timestamp":1779144750936,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data supporting a link between body-fat distribution changes and cardiovascular disease risk in HIV- infected patients are scarce and contradictory. We evaluated endothelial dysfunction, an early event in the development of atherosclerosis, and pro- atherosclerotic plasma biomarkers in HIV-infected patients with lipodystrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HIV-infected patients with and without lipodystrophy were prospectively enrolled. Endothelial function was measured through flow-mediated dilatation (FMD) of the brachial artery. Plasma levels of several biomarkers of inflammation, endothelial activation and coagulation associated with adipose tissue and endothelial dysfunction were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 110 patients, 55 of them with lipodystrophy. FMD was significantly lower in patients with lipodystrophy than in those without lipodystrophy (median [IQR] 3.1% [0.4\u20138.9] versus 6.3% [3.3\u201310.7]; P=0.004). Patients with isolated lipoatrophy exhibited the lowest FMD (2.6% [0\u20136.6]; P\n                      <jats:sub>Kruskal\u2013Wallis<\/jats:sub>\n                      =0.02). Lipodystrophy was associated with significantly higher plasma levels of interleukin 6 (IL-6) and plasminogen activator inhibitor 1 (PAI-1) and lower levels of adiponectin; severe lipodystrophy was associated with higher concentrations of vascular cell adhesion molecule 1 (sVCAM-1). There was an inverse correlation between FMD and IL-6 (Spearman's rho =-0.26; P=0.007). In a multivariate regression model with the lowest quartile of FMD as the dependent variable and lipodystrophy, traditional cardiovascular risk factors, 10-year Framingham risk score, pro- atherosclerotic biomarkers and HIV-related variables as predictors, the only independent predictor of endothelial dysfunction was lipodystrophy (odds ratio 5.22, 95% confidence interval 1.76\u201315.46; P=0.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lipodystrophy is associated with endothelial dysfunction, independently of the presence of traditional cardiovascular risk factors. This finding and the accompanying profile of pro-atherosclerotic biomarkers support an increased cardiovascular risk in HIV-infected patients with lipodystrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp1491","type":"journal-article","created":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T08:43:06Z","timestamp":1265791386000},"page":"101-110","source":"Crossref","is-referenced-by-count":35,"title":["Endothelial function is impaired in HIV-infected patients with lipodystrophy"],"prefix":"10.1177","volume":"15","author":[{"given":"Mar","family":"Masi\u00e1","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche, Department of Clinical Medicine, University Miguel Hern\u00e1ndez, Elche, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Padilla","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche, Department of Clinical Medicine, University Miguel Hern\u00e1ndez, Elche, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Biochemistry Section, Hospital General Universitario de Elche, Elche, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Jarrin","sequence":"additional","affiliation":[{"name":"National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Bernal","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital General Universitario de Elche, Department of Clinical Medicine, University Miguel Hern\u00e1ndez, Elche, Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natividad","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Biochemistry 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