{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:35:11Z","timestamp":1784039711413,"version":"3.55.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cidofovir (CDV) is an acyclic nucleoside phosphonate that exhibits a potent antiviral activity against several DNA viruses. In previous studies, CDV has been shown to significantly reduce the clinical severity and the viral shedding in primary caprine herpes-virus type-1 (CpHV-1) infection in goats. CpHV-1 is an \u03b1-herpesvirus showing many biological similarities with human herpesvirus type-2 (HHV-2); therefore, studies conducted on the CpHV-1 goat model could provide useful information on the pathogenesis, therapy and prevention of HHV-2 infection in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CDV was administered to goats infected by vaginal route with CpHV-1. Real-time PCR was carried out on sacral ganglia from CpHV-1-infected goats to detect and quantify latent CpHV-1 DNA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Viral DNA was variably found in all five pairs of sacral ganglia, with a more frequent involvement of the third and fourth pair. In CDV-treated goats, the amount of CpHV-1 DNA did not appear to be related either to the severity of the clinical signs or the titre of the virus shed during primary CpHV-1 infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CDV failed to prevent CpHV-1 latency. Thus, vaginal CDV administration during primary herpesvirus infection, although providing immediate clinical benefits to the host might not influence the establishment of latency and, consequently, the rate of recurrent infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp1611","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T13:26:39Z","timestamp":1281533199000},"page":"785-788","source":"Crossref","is-referenced-by-count":11,"title":["<b>Cidofovir does not prevent caprine herpesvirus type-1 neural latency in goats<\/b>"],"prefix":"10.1177","volume":"15","author":[{"given":"Michele","family":"Camero","sequence":"first","affiliation":[{"name":"Department of Veterinary Public Health, Faculty of Veterinary Medicine, University of Bari, Valenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Crescenzo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health, Faculty of Veterinary Medicine, University of Bari, Valenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Marinaro","sequence":"additional","affiliation":[{"name":"Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanit\u00e0, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Tarsitano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health, Faculty of Veterinary Medicine, University of Bari, Valenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Lucia","family":"Bellacicco","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health, Faculty of Veterinary Medicine, University of Bari, Valenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Armenise","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health, Faculty of Veterinary Medicine, University of Bari, Valenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canio","family":"Buonavoglia","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health, Faculty of Veterinary Medicine, University of Bari, Valenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tempesta","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health, Faculty of Veterinary Medicine, University of Bari, Valenzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"bibr1-IMP1611","first-page":"847","volume":"35","author":"Saito J.K.","year":"1974","journal-title":"Am J Vet Res"},{"key":"bibr2-IMP1611","doi-asserted-by":"publisher","DOI":"10.1016\/S0147-9571(98)00029-0"},{"key":"bibr3-IMP1611","unstructured":"Tempesta M., Cirone F., Greco G., Martella V., Pratelli A., Buonavoglia C. A study on the latency of caprine herpesvirus 1 in naturally infected goats.\n                      8th International Congress of Mediterranean Federation for Health and Production of Ruminants\n                      . 27\u201330 April 2000, Giardini Naxos, Sicily, Italy. Abstract 147."},{"key":"bibr4-IMP1611","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0450.2000.00334.x"},{"key":"bibr5-IMP1611","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.5.1598-1599.1999"},{"key":"bibr6-IMP1611","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.59.061606.095540"},{"key":"bibr7-IMP1611","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.04.008"},{"key":"bibr8-IMP1611","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.10.006"},{"key":"bibr9-IMP1611","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1877"},{"key":"bibr10-IMP1611","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5070\/D32VZ9C4HZ","volume":"6","author":"Zabawski E.J.","year":"2000","journal-title":"Dermatol Online J"},{"key":"bibr11-IMP1611","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1177\/135965350701200616","volume":"12","author":"Tempesta M.","year":"2007","journal-title":"Antivir Ther"},{"key":"bibr12-IMP1611","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.11.001"},{"key":"bibr13-IMP1611","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00725-08"},{"key":"bibr14-IMP1611","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2004.09.018"},{"key":"bibr15-IMP1611","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2007.10.021"},{"key":"bibr16-IMP1611","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2005.02.006"},{"key":"bibr17-IMP1611","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.10.031"},{"key":"bibr18-IMP1611","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.4.2760-2764.1998"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:49:33Z","timestamp":1777380573000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP1611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.3851\/IMP1611"],"URL":"https:\/\/doi.org\/10.3851\/imp1611","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}