{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:37:28Z","timestamp":1777451848725,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Unexpected cases of severe liver disease in HIV-infected patients have been reported and an association with didanosine (ddI) has been suggested. Transient elastography (TE) might detect patients harbouring such a condition. Our objective was to search for the presence of abnormal liver stiffness (LS) in a cohort of HIV-infected patients without HBV or HCV coinfection and to assess the related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional prospective study was conducted. LS was assessed by TE in 258 HIV-infected patients without HBV or HCV coinfection and with no evidence of acute hepatotoxicity or other origins of liver disease. LS values \u22657.2 kPa were considered abnormal. Multivariate analyses were performed to identify factors associated with abnormal LS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Abnormal LS was observed in 29 (11.2%) patients. A total of 18 (16.4%) patients previously treated with ddI and 11 (7.4%) of those who never received ddI had LS values \u22657.2 kPa ( P=0.02). The prevalence of abnormal LS was higher in patients previously treated with abacavir than in those who had never received abacavir (15 [21.7%] versus 14 [7.4%]; P=0.001). After multivariate analyses, age (adjusted odds ratio [AOR] 1.05, 95% confidence interval [CI] 1.002-1.1; P=0.004) alcohol intake &gt;50 g\/day (AOR 7.2, 95% CI 2.6-19.7; P&lt;0.0001), CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell count &lt;200 cells\/ml (AOR 3.4, 95% CI 1.06-11.007; P=0.03), time on ddI treatment (AOR 1.31, 95% CI 1.12-1.52; P=0.001) and previous abacavir exposure (AOR 3.01, 95% CI 1.18-7.67; P=0.02) were independently associated with abnormal LS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of abnormal LS in HIV-infected patients without HBV or HCV coinfection is substantial. Long-term exposure to ddI is a major cause of liver damage in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp1612","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T13:00:44Z","timestamp":1281531644000},"page":"753-763","source":"Crossref","is-referenced-by-count":41,"title":["Prevalence and Risk Factors for Abnormal Liver Stiffness in HIV-infected Patients without Viral Hepatitis Coinfection: Role of Didanosine"],"prefix":"10.1177","volume":"15","author":[{"name":"Grupo Andaluz para el Estudio de las Hepatitis V\u00edricas de la Sociedad Andaluza de Enfermedades Infecciosas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00e1s","family":"Merchante","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario de Valme, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"P\u00e9rez-Camacho","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A","family":"Mira","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario de Valme, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rivero","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Mac\u00edas","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario de Valme, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngela","family":"Camacho","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"G\u00f3mez-Mateos","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario de Valme, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milagros","family":"Garc\u00eda-L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n","family":"Torre-Cisneros","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A","family":"Pineda","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario de Valme, Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"bibr1-IMP1612","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803263381301"},{"key":"bibr2-IMP1612","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02069-9"},{"key":"bibr3-IMP1612","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21757"},{"key":"bibr4-IMP1612","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.15.1632"},{"key":"bibr5-IMP1612","doi-asserted-by":"publisher","DOI":"10.1086\/318501"},{"key":"bibr6-IMP1612","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200308150-00009"},{"key":"bibr7-IMP1612","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000221683.44940.62"},{"key":"bibr8-IMP1612","doi-asserted-by":"publisher","DOI":"10.1177\/135965350801300111"},{"key":"bibr9-IMP1612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01428.x"},{"key":"bibr10-IMP1612","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3280119e47"},{"key":"bibr11-IMP1612","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3281e7ed64"},{"key":"bibr12-IMP1612","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.018"},{"key":"bibr13-IMP1612","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20506"},{"key":"bibr14-IMP1612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01802.x"},{"key":"bibr15-IMP1612","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21151"},{"key":"bibr16-IMP1612","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.126417"},{"key":"bibr17-IMP1612","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21420"},{"key":"bibr18-IMP1612","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000194238.15831.c7"},{"key":"bibr19-IMP1612","doi-asserted-by":"publisher","DOI":"10.1086\/521857"},{"key":"bibr20-IMP1612","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.07.031"},{"key":"bibr21-IMP1612","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21665"},{"key":"bibr22-IMP1612","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20857"},{"key":"bibr23-IMP1612","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.008"},{"key":"bibr24-IMP1612","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90084-O"},{"key":"bibr25-IMP1612","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110512"},{"key":"bibr26-IMP1612","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.26517"},{"key":"bibr27-IMP1612","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.7.1035"},{"key":"bibr28-IMP1612","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2003.00413.x"},{"key":"bibr29-IMP1612","doi-asserted-by":"publisher","DOI":"10.1086\/380130"},{"key":"bibr30-IMP1612","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200403260-00007"},{"key":"bibr31-IMP1612","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200411050-00008"},{"key":"bibr32-IMP1612","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1177\/135965350601100701","volume":"11","author":"Mac\u00edas 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Impact of specific NRTI and PI exposure on the risk of myocardial infarction: a case-control study nested within FHDH ANRS CO4.\n                      16th Conference on Retroviruses and Opportunistic Infections\n                      . 8\u201311 February 2009, Montreal, QC, Canada. Abstract 43LB."},{"key":"bibr41-IMP1612","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31819ff0e6"},{"key":"bibr42-IMP1612","unstructured":"Benson C., Ribaudo H., Zheng E. No association of abacavir use with risk of myocardial infarction or severe cardiovascular disease events: results from ACTG A5001.\n                      16th Conference on Retroviruses and Opportunistic Infections\n                      . 8\u201311 February 2009, Montreal, QC, Canada. Abstract 721."},{"key":"bibr43-IMP1612","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.111302"},{"key":"bibr44-IMP1612","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328331a5d0"},{"key":"bibr45-IMP1612","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.11.020"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:49:34Z","timestamp":1777380574000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP1612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.3851\/IMP1612"],"URL":"https:\/\/doi.org\/10.3851\/imp1612","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}