{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:57:38Z","timestamp":1790225858619,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on liver fibrosis evolution in HIV\u2013HBV-coinfected patients treated with tenofovir disoproxil fumarate (TDF) are scarce. The effect of TDF on liver fibrosis in 148 HIV\u2013HBV-coinfected patients was prospectively evaluated using Fibrometer\u00ae scores and liver biopsies in a subset of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The mean change from baseline (\u0394) in Fibrometer score was modelled using a generalized estimating equation. Homogeneous continuous-time Markov models were used to study risk factors for regression or progression of liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow-up of patients treated with TDF was 29.5 months (25th\u201375th percentile 20.9\u201338.1). The distribution of scored fibrosis at TDF initiation was F0\u2013F1 n=65, F2 n=37 and F3\u2013F4 n=46. In patients with a baseline fibrosis score of F3\u2013F4, Fibrometer score decreased with a triphasic shape (Fibrometer \u0394 at 12, 24 and 36 months after TDF initiation was -0.079, -0.069 and -0.102, respectively). Despite duration on TDF, higher fibrosis scores were noted in F3\u2013F4 patients with high HBV viral load and HDV coinfection, and in F0\u2013F2 patients who had high HBV viral load and low CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell count. Progression in fibrosis score over time was influenced by age, alcohol consumption, low CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell count and HCV coinfection, whereas HDV coinfection and longer duration of HBV infection prevented fibrosis regression. No influence of antiretrovirals other than TDF was found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of TDF in HIV\u2013HBV-coinfected patients led to a decrease in liver fibrosis score in patients with advanced fibrosis or cirrhosis. Sustainability of its direct antiviral and indirect antifibrotic effects on the liver need to be studied further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp1649","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T09:12:15Z","timestamp":1283245935000},"page":"963-974","source":"Crossref","is-referenced-by-count":37,"title":["Liver Fibrosis Changes in HIV\u2013HBV-Coinfected Patients: Clinical, Biochemical and Histological Effect of Long-Term Tenofovir Disoproxil Fumarate Use"],"prefix":"10.1177","volume":"15","author":[{"given":"Anders","family":"Boyd","sequence":"first","affiliation":[{"name":"INSERM UMR-S707, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Lasnier","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Saint Antoine Hospital, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Michel","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases, Saint Louis Hospital, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Lascoux-Combe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Saint Louis Hospital, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bonnard","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases, Tenon Hospital, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Miailhes","sequence":"additional","affiliation":[{"name":"Hepatology Department, H\u00f4tel-Dieu, Hospices Civils of Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Wendum","sequence":"additional","affiliation":[{"name":"Anatomo-pathology 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