{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:41:44Z","timestamp":1777452104253,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data are inconclusive whether treatment with HAART induces functional recovery of HIV-specific T-cells. Since the introduction of HAART, a marked decrease of cytomegalovirus (CMV) disease \u2013 for which untreated HIV-infected individuals are at increased risk \u2013 is observed, suggesting that this treatment influences CMV-specific T-cell immunity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To study potential functional recovery of HIV-and CMV-specific T-cells, CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      T-cell responses were measured longitudinally after in vitro expansion using gag, pp65 and IE1 peptide pools, during HIV infection and after long-term HAART.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HIV-specific T-cell function, measured by interferon (IFN)-\u03b3 production, was low after initiation of HAART. Interestingly, the cytotoxic function \u2013 measured by CD107a expression \u2013 of these T-cells temporarily increased after start of treatment, suggesting some functional recovery. The pp65-specific CD8\n                      <jats:sup>+<\/jats:sup>\n                      T-cell responses tended to decrease during HIV infection, whereas pp65-specific CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell responses decreased upon treatment with HAART. Both pp65-specific CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      T-cell responses were low after initiation of HAART compared to healthy controls. By contrast, IE1-specific CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell responses increased during the course of HIV infection. After initiation of HAART, IE1-specific T-cell responses decreased, but IE1-specific CD8\n                      <jats:sup>+<\/jats:sup>\n                      T-cells seemed increased compared to healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that HIV-infection leads to an altered CMV biology, affecting pp65- and IE1-specific T-cell responses in a different way, which is not restored by treatment with long-term HAART.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp1800","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T06:42:32Z","timestamp":1305700952000},"page":"565-575","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Influence of HIV Infection on Cytomegalovirus-Specific Immunity: T-Cell Responses to Pp65 and Ie1 before and after Haart May Refect Altered Cytomegalovirus Biology"],"prefix":"10.1177","volume":"16","author":[{"given":"Jolanda","family":"Scherrenburg","sequence":"first","affiliation":[{"name":"Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid MM","family":"Schellens","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"van Baarle","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands"},{"name":"Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,5,1]]},"reference":[{"key":"bibr1-IMP1800","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604183341602"},{"key":"bibr2-IMP1800","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512073332303"},{"key":"bibr3-IMP1800","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199812000-00010"},{"key":"bibr4-IMP1800","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/135965350601100104","volume":"11","author":"Jansen C.A.","year":"2006","journal-title":"Antivir Ther"},{"key":"bibr5-IMP1800","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5359.2103"},{"key":"bibr6-IMP1800","doi-asserted-by":"publisher","DOI":"10.1038\/8400"},{"key":"bibr7-IMP1800","doi-asserted-by":"publisher","DOI":"10.1086\/515587"},{"key":"bibr8-IMP1800","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.4049\/jimmunol.162.3.1780","volume":"162","author":"Gray 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