{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:50:59Z","timestamp":1778946659340,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastrointestinal haemorrhage from ruptured esophageal varices (EV) is a significant cause of morbidity and mortality in patients with HCV-related cirrhosis. The risk of developing EV and bleeding is influenced by hepatitis severity, which can be attenuated by successful interferon (IFN) therapy. Our aim was to prospectively assess whether a successful IFN therapy modifies development and\/or progression of EV in patients with HCV-related compensated cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Child\u2013Pugh A patients with either no or small (F1) EV underwent surveillance with repeated endoscopy during and after completion of IFN-based therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 127 patients (59 years, 79 males, 65 HCV-1\/4 and 17 F1 EV) received weight-based ribavirin (RBV) combined with either IFN-\u03b12b 3 MU three times per week ( n=36), weekly pegylated (PEG)-IFN-\u03b12b 1.5 \u03bcg\/kg ( n=68) or weekly PEG-IFN-\u03b12a 180 \u03bcg ( n=23). Patients were followed-up for 18\u2013108 months after treatment completion with a median endoscopic follow-up of 68 months for the 62 patients with a sustained virological response (SVR) and 57 months for the 65 non-SVR patients ( P=0.3). De novo EV developed in 10 (9.1%) patients including 2\/57 SVR and 8\/53 non-SVR (3.5% versus 15.1%; P=0.047), whereas EV progressed in size in 3 patients, including 1\/5 SVR and 2\/12 non-SVR ( P=0.87). Two non-SVR patients bled from EV and one died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A successful IFN therapy prevents or delays the de novo onset of EV in patients with compensated cirrhosis due to HCV, but does not abrogate the need for continued endoscopic surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp1807","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:47:37Z","timestamp":1308343657000},"page":"677-684","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["The Course of Esophageal Varices in Patients with Hepatitis C Cirrhosis Responding to Interferon\/ Ribavirin Therapy"],"prefix":"10.1177","volume":"16","author":[{"given":"Roberta","family":"D'Ambrosio","sequence":"first","affiliation":[{"name":"AM Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Aghemo","sequence":"additional","affiliation":[{"name":"AM Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Rumi","sequence":"additional","affiliation":[{"name":"Division of Hepatology, Ospedale San Giuseppe, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Primignani","sequence":"additional","affiliation":[{"name":"AM Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Dell'Era","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Clinical Sciences, Ospedale L. Sacco, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Lampertico","sequence":"additional","affiliation":[{"name":"AM Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Francesca","family":"Donato","sequence":"additional","affiliation":[{"name":"AM Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"De Nicola","sequence":"additional","affiliation":[{"name":"AM Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Maria","family":"Prati","sequence":"additional","affiliation":[{"name":"AM Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"de Franchis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Clinical Sciences, Ospedale L. Sacco, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Colombo","sequence":"additional","affiliation":[{"name":"AM Migliavacca Center for Liver Disease, First Division of Gastroenterology, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,7,1]]},"reference":[{"issue":"1","key":"bibr1-IMP1807","first-page":"2S","volume":"26","year":"2007","journal-title":"Hepatology"},{"issue":"1","key":"bibr2-IMP1807","first-page":"3","volume":"31","author":"EASL International Consensus Conference on Hepatitis C.","year":"1999","journal-title":"J Hepatol"},{"key":"bibr3-IMP1807","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260704"},{"key":"bibr4-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80369-9"},{"issue":"1","key":"bibr5-IMP1807","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1002\/hep.1840360706","volume":"36","author":"Seeff L.B.","year":"2002","journal-title":"Hepatology"},{"key":"bibr6-IMP1807","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21176"},{"key":"bibr7-IMP1807","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.020263"},{"key":"bibr8-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(81)80123-0"},{"key":"bibr9-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3528(97)90038-5"},{"key":"bibr10-IMP1807","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.044"},{"key":"bibr11-IMP1807","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810133191505"},{"key":"bibr12-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00420-8"},{"key":"bibr13-IMP1807","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.004"},{"key":"bibr14-IMP1807","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01775.x"},{"key":"bibr15-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.05.009"},{"key":"bibr16-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80320-7"},{"key":"bibr17-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80127-9"},{"key":"bibr18-IMP1807","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280339"},{"issue":"3","key":"bibr19-IMP1807","first-page":"iii1","volume":"46","author":"Jalan R.","year":"2000","journal-title":"Gut"},{"key":"bibr20-IMP1807","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.11.1298"},{"key":"bibr21-IMP1807","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20073"},{"key":"bibr22-IMP1807","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21492"},{"key":"bibr23-IMP1807","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-10-200711200-00003"},{"key":"bibr24-IMP1807","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-2-200501180-00009"},{"key":"bibr25-IMP1807","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1177\/135965350601100811","volume":"11","author":"Yu M.L.","year":"2006","journal-title":"Antivir Ther"},{"key":"bibr26-IMP1807","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34785"},{"key":"bibr27-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80302-9"},{"key":"bibr28-IMP1807","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23528"},{"key":"bibr29-IMP1807","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00743.x"},{"key":"bibr30-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.02.022"},{"key":"bibr31-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80226-6"},{"key":"bibr32-IMP1807","doi-asserted-by":"publisher","DOI":"10.1007\/BF02468653"},{"key":"bibr33-IMP1807","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(87)80015-6"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:50:09Z","timestamp":1777380609000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP1807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.3851\/IMP1807"],"URL":"https:\/\/doi.org\/10.3851\/imp1807","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}