{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:42:44Z","timestamp":1777452164696,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite a rising incidence of acute HCV in patients infected with HIV, the optimal therapeutic strategy (pegylated interferon-\u03b1 [PEG-IFN-\u03b1] monotherapy or in combination with ribavirin) is still under debate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 23 HIV-infected patients were prospectively diagnosed with acute HCV and treated with PEG-IFN-\u03b12a monotherapy (180 \u03bcg\/week) for 24 or 48 weeks. Add-on ribavirin was allowed from week 4 of therapy onwards. There were three patients who were not included for different reasons. Blood samples were routinely drawn for viral load measurement and IL28B polymorphism analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Spontaneous viral clearance occurred in 1 (4%) patient. Nineteen patients (13 genotype 1 and 6 genotype 4) received treatment with PEG-IFN-\u03b1 monotherapy (3 with add-on ribavirin) resulting in a rapid virological response (HCV RNA&lt;50 IU\/ml at week 4) in 7 (37%) patients. A sustained virological response (SVR) was reached in 7 (37%) patients, whereas 9 (47%) patients were null-responders to treatment (that is, &lt;2 log\n                      <jats:sub>10<\/jats:sub>\n                      drop in HCV RNA at week 12 of therapy). The unfavourable G allele of the IL28B polymorphism rs8099917 was detected in 66% of the non-responders. In case of re-emergence of HCV viraemia after treatment discontinuation, sequence analysis of quasispecies confirmed an HCV relapse in 3 patients while 2 patients were re-infected by their previously non-responding partner.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PEG-IFN-\u03b1 monotherapy resulted in a low SVR rate and a high percentage of null-response, whereas non-SVR was associated with a polymorphism in the IL28B gene (rs8099917).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp1843","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T09:48:09Z","timestamp":1309945689000},"page":"979-988","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Pegylated Interferon-\u03b1 Monotherapy Leads to Low Response Rates in HIV-Infected Patients with Acute Hepatitis C"],"prefix":"10.1177","volume":"16","author":[{"given":"Joop E","family":"Arends","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands"},{"name":"Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander","family":"van Assen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, University Medical Center Groningen, Groningen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cari J","family":"Stek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, University Medical Center Groningen, Groningen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemarie MJ","family":"Wensing","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin H","family":"Fransen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands"},{"name":"Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid M","family":"Schellens","sequence":"additional","affiliation":[{"name":"Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne NM","family":"Spijkers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands"},{"name":"Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Mudrikova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"van Baarle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands"},{"name":"Department of Immunology, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman G","family":"Sprenger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, University Medical Center Groningen, Groningen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy IM","family":"Hoepelman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,10,1]]},"reference":[{"key":"bibr1-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3281053a0c"},{"key":"bibr2-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282ef3873"},{"key":"bibr3-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832e5631"},{"key":"bibr4-IMP1843","doi-asserted-by":"publisher","DOI":"10.1086\/518796"},{"key":"bibr5-IMP1843","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2007.00535.x"},{"key":"bibr6-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3281084e4d"},{"key":"bibr7-IMP1843","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2006.00802.x"},{"key":"bibr8-IMP1843","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011232"},{"key":"bibr9-IMP1843","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21043"},{"key":"bibr10-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283036cac"},{"key":"bibr11-IMP1843","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp385"},{"key":"bibr12-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000226956.02719.fd"},{"key":"bibr13-IMP1843","unstructured":"Fierer D.S., Fishman S., Uriel A.J. Characterization of an Outbreak of Acute HCV Infection in HIV-infected Men in New York City.\n                      16th Conference on Retroviruses and Opportunistic Infections\n                      . 8\u201311 February 2009, Montreal, QC, Canada. Abstract 802."},{"key":"bibr14-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000174930.64145.a9"},{"key":"bibr15-IMP1843","unstructured":"Lambers F., van den Berk G., van der Meer J. Treatment Outcome of Acute Hepatitis C Virus Infection in HIV-infected MSM: The Effect of Treatment Length.\n                      17th Conference on Retroviruses and Opportunistic Infections\n                      . 16\u201319 February 2010, San Francisco, CA, USA. Abstract 641."},{"key":"bibr16-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000191281.77954.27"},{"key":"bibr17-IMP1843","doi-asserted-by":"publisher","DOI":"10.1086\/596770"},{"key":"bibr18-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328330ed24"},{"key":"bibr19-IMP1843","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1468-1293.2005.00297_2.x","volume":"6","author":"Danta M.","year":"2005","journal-title":"HIV Med"},{"key":"bibr20-IMP1843","doi-asserted-by":"publisher","DOI":"10.1086\/598995"},{"key":"bibr21-IMP1843","doi-asserted-by":"publisher","DOI":"10.1086\/600399"},{"key":"bibr22-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000200541.40633.56"},{"key":"bibr23-IMP1843","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2005.00580.x"},{"key":"bibr24-IMP1843","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1177\/135965350601100817","volume":"11","author":"Vogel M.","year":"2006","journal-title":"Antivir Ther"},{"key":"bibr25-IMP1843","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328330a8e8"},{"key":"bibr26-IMP1843","doi-asserted-by":"publisher","DOI":"10.1038\/nature08463"},{"key":"bibr27-IMP1843","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"bibr28-IMP1843","doi-asserted-by":"publisher","DOI":"10.1038\/ng.447"},{"key":"bibr29-IMP1843","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.056"},{"key":"bibr30-IMP1843","doi-asserted-by":"publisher","DOI":"10.1038\/ng.449"},{"key":"bibr31-IMP1843","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.03.003"},{"key":"bibr32-IMP1843","unstructured":"Arends J.E., Mudrikova T., Wensing A.M.J., Wind C.M., van Baarle D., Hoepelman A.I.M. High percentage of non-response with peginterferon-alfa-2a monotherapy for the treatment of acute hepatitis C in HIV infected patients.\n                      49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)\n                      . 12\u201315 September 2009, San Francisco, CA, USA. Abstract 2458."},{"key":"bibr33-IMP1843","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-251-9_3"},{"key":"bibr34-IMP1843","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.11.016"},{"key":"bibr35-IMP1843","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00668-1"},{"key":"bibr36-IMP1843","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.11.010"},{"key":"bibr37-IMP1843","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2007.0011"},{"key":"bibr38-IMP1843","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05398.x"},{"key":"bibr39-IMP1843","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn421"},{"key":"bibr40-IMP1843","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.016"},{"key":"bibr41-IMP1843","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02283.x"},{"key":"bibr42-IMP1843","unstructured":"Nattermann J., Vogel M., Baumgarten A. Genetic variation in IL28B and treatment-induced clearance of HCV in HCV\/HIV co-infected patients.\n                      17th Conference on Retroviruses and Opportunistic Infections\n                      . 16\u201319 February 2010, San Francisco, CA, USA. Abstract 164."},{"key":"bibr43-IMP1843","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.01.059"},{"key":"bibr44-IMP1843","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22729"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:50:17Z","timestamp":1777380617000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP1843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.3851\/IMP1843"],"URL":"https:\/\/doi.org\/10.3851\/imp1843","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}