{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:44:01Z","timestamp":1777452241214,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>Herpes simplex virus (HSV) hepatitis is an uncommon cause of acute liver failure (ALF), primarily affecting immunocompromised patients. So far, 148 cases have been published, of which 9 underwent liver transplantation (LT). The reported post-transplant survival is poor, with over 60% dying in the first year. Dosing and duration of antiviral therapy after LT are not established. Concerns include both the risk of hepatic recurrence after LT and emergence of viral resistance during prolonged therapy. HSV DNA plasma levels might be helpful to monitor therapeutic response and guide duration of therapy. We present a case of ALF complicating a primary HSV-1 infection in an immunocompetent host, who required emergency LT. We further discuss the value of measuring serial HSV DNA plasma loads to monitor antiviral therapy.<\/jats:p>","DOI":"10.3851\/imp1922","type":"journal-article","created":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T11:53:39Z","timestamp":1319198019000},"page":"401-404","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Herpes Simplex Virus Load to Monitor Antiviral Treatment after Liver Transplantation for Acute Herpetic Hepatitis"],"prefix":"10.1177","volume":"17","author":[{"given":"Juan","family":"Ambrosioni","sequence":"first","affiliation":[{"name":"Service of Infectious Diseases, Department of Medical Specialities, University Hospitals of Geneva, Geneva, Switzerland"},{"name":"Service of Transplantation, Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland"},{"name":"Laboratory of Virology, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases, Department of Medical Specialities, University Hospitals of Geneva, Geneva, Switzerland"},{"name":"Laboratory of Virology, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Giostra","sequence":"additional","affiliation":[{"name":"Service of Transplantation, Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland"},{"name":"Service of Gastroenterology, Department of Medical Specialities, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Meylan","sequence":"additional","affiliation":[{"name":"Institut de Microbiologie, University Hospital Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Mentha","sequence":"additional","affiliation":[{"name":"Service of Transplantation, Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Toso","sequence":"additional","affiliation":[{"name":"Service of Transplantation, Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Genevay-Infante","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Department of Genetic Medicine and Laboratory, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rubbia-Brandt","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Department of Genetic Medicine and Laboratory, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"van Delden","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases, Department of Medical Specialities, University Hospitals of Geneva, Geneva, Switzerland"},{"name":"Service of Transplantation, Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"key":"bibr1-IMP1922","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04084.x"},{"key":"bibr2-IMP1922","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-007-6366-7"},{"key":"bibr3-IMP1922","first-page":"620","volume":"31","author":"Grimm B.","year":"2008","journal-title":"Onkologie"},{"key":"bibr4-IMP1922","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00486.x"},{"key":"bibr5-IMP1922","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21250"},{"key":"bibr6-IMP1922","first-page":"A55","volume":"153","author":"Ozokcu L.","year":"2009","journal-title":"Ned Tijdschr Geneeskd"},{"key":"bibr7-IMP1922","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.01108.x"},{"key":"bibr8-IMP1922","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21567"},{"key":"bibr9-IMP1922","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20545"},{"key":"bibr10-IMP1922","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20567"},{"key":"bibr11-IMP1922","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.10.010"},{"key":"bibr12-IMP1922","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.06.001"},{"key":"bibr13-IMP1922","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030162"},{"key":"bibr14-IMP1922","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308057100"},{"key":"bibr15-IMP1922","unstructured":"Health Resources and Services Administration. US organ procurement and transplantation network and the scientific registry of transplant recipients. OPTN\/SRTR 2009 annual report 1998\u20132008. (Accessed 5 December 2010.) Available from www.ustransplant.org\/annual-reports\/comment\/."},{"key":"bibr16-IMP1922","doi-asserted-by":"publisher","DOI":"10.1016\/j.hep.2011.02.029"},{"key":"bibr17-IMP1922","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2009.00951.x"},{"key":"bibr18-IMP1922","doi-asserted-by":"publisher","DOI":"10.1086\/606053"},{"key":"bibr19-IMP1922","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.10.031"},{"key":"bibr20-IMP1922","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2006.00133.x"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1922","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP1922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:50:30Z","timestamp":1777380630000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP1922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,1]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.3851\/IMP1922"],"URL":"https:\/\/doi.org\/10.3851\/imp1922","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,1]]}}}