{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:44:06Z","timestamp":1777452246343,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lipid disorders are frequent in HIV-1-infected patients taking combination antiretroviral therapy (cART) that includes protease inhibitors (PIs). The presence of small dense low-density lipoprotein particles might be an important predictive marker of cardiovascular disease in this setting. This cross-sectional substudy of the ANRS 126 trial was designed to identify variables influencing LDL diameter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 81 stable HIV-1-infected patients with dyslipidaemia (LDL-cholesterol &gt;4.1 mmol\/l, triglycerides &lt;8.8 mmol\/l) receiving PI-including cART regimens and no lipid-lowering drugs. LDL diameter was assessed by gradient gel electrophoresis. Relationships between LDL diameter and demographic, metabolic and HIV-related variables were identified by using non-parametric univariate tests and multiple linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In univariate analysis, LDL diameter was related to demographic variables, triglyceride (TG) levels, high-density lipoprotein cholesterol (HDL-c) levels, and the numbers and duration of exposure to nucleoside reverse transcriptase inhibitors and PIs. In multivariable linear regression analysis, LDL diameter was negatively associated with the TG level ( P&lt;0.0001) and positively associated with the HDL-c level ( P&lt;0.0001). For each 1-mmol\/l increase in TG, LDL diameter fell by 0.281 nm. Conversely, for each 1-mmol\/l increase in HDL-c, LDL diameter rose by 1.175 nm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher TG and lower HDL-c levels are associated with smaller LDL particle diameter. Small-diameter LDL particles could contribute to early atherogenic processes in HIV-1-infected patients on cART.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp2065","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T07:53:46Z","timestamp":1328774026000},"page":"855-860","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Determinants of Low-Density Lipoprotein Particle Diameter during Antiretroviral Therapy Including Protease Inhibitors in HIV-1-Infected Patients"],"prefix":"10.1177","volume":"17","author":[{"given":"Randa","family":"Bittar","sequence":"first","affiliation":[{"name":"Unit\u00e9 Fonctionnelle de Biochimie des Maladies M\u00e9taboliques, Service de Biochimie M\u00e9tabolique, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"UPMC Univ Paris 06, UMR S 939, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Giral","sequence":"additional","affiliation":[{"name":"UPMC Univ Paris 06, UMR S 939, Paris, France"},{"name":"Unit\u00e9 de Pr\u00e9vention Cardiovasculaire, Service d'Endocrinologie M\u00e9tabolisme, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Aslangul","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, H\u00f4tel-Dieu, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"Universit\u00e9 Paris Descartes, rue de l'\u00e9cole de M\u00e9decine, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lambert","family":"Assoumou","sequence":"additional","affiliation":[{"name":"INSERM, U 943, Paris, France"},{"name":"UPMC Univ Paris 06, UMR S 943, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc-Antoine","family":"Valantin","sequence":"additional","affiliation":[{"name":"INSERM, U 943, Paris, France"},{"name":"UPMC Univ Paris 06, UMR S 943, France"},{"name":"Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Kalmykova","sequence":"additional","affiliation":[{"name":"INSERM, U 943, Paris, France"},{"name":"UPMC Univ Paris 06, UMR S 943, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Fesel-Fouquier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Fonctionnelle de Biochimie des Maladies M\u00e9taboliques, Service de Biochimie M\u00e9tabolique, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Costagliola","sequence":"additional","affiliation":[{"name":"INSERM, U 943, Paris, France"},{"name":"UPMC Univ Paris 06, UMR S 943, France"},{"name":"Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Bonnefont-Rousselot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Fonctionnelle de Biochimie des Maladies M\u00e9taboliques, Service de Biochimie M\u00e9tabolique, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"EA 4466, D\u00e9partement de Biologie Exp\u00e9rimentale, M\u00e9tabolique et clinique, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the ANRS 126 study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"bibr1-IMP2065","first-page":"1045","volume":"74","author":"Grunfeld C.","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr2-IMP2065","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R300019-JLR200"},{"key":"bibr3-IMP2065","first-page":"1423","volume":"76","author":"Feingold K.R.","year":"1993","journal-title":"J Clin Endocrinol 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M., Ordo\u00f1ez J., Martinez E. Comprehensive lipid evaluation in patients switching from PI\/r-based cART to a Ral-based cART: The SPIRAL Substudy.\n                      18th Conference on Retroviruses and Opportunistic Infections\n                      . 27 February \u2013 2 March, 2011, Boston, MA, USA. Abstract 820."},{"key":"bibr34-IMP2065","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833fcb3b"},{"key":"bibr35-IMP2065","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1273"},{"key":"bibr36-IMP2065","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1177\/135965350501000508","volume":"10","author":"Umpleby A.M.","year":"2005","journal-title":"Antivir Ther"},{"key":"bibr37-IMP2065","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0085-3"},{"key":"bibr38-IMP2065","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.10.018"},{"key":"bibr39-IMP2065","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.05.001"},{"key":"bibr40-IMP2065","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.059949"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:50:43Z","timestamp":1777380643000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP2065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.3851\/IMP2065"],"URL":"https:\/\/doi.org\/10.3851\/imp2065","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}