{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:47:11Z","timestamp":1777452431453,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients coinfected with HIV and HCV are at risk for developing portal hypertension (PHT), hyper-dynamic circulation and pulmonary arterial hypertension (PAH). Data on the influence of antiviral therapy with pegylated interferon-\u03b1 (PEG-IFN-\u03b1) and ribavirin (RBV) are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Haemodynamic parameters, including hepatic venous pressure gradient (HVPG), pulmonary arterial pressure (PAP\n                      <jats:sub>mean<\/jats:sub>\n                      ), cardiac output (CO) and systemic vascular resistance (SysVR), were prospectively evaluated before and after PEG-IFN-\u03b1+RBV therapy in 80 HIV\u2013HCV-coinfected patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline evaluation showed a mean HVPG of 4.7 mmHg, CO of 6.15 l\/min and PAP\n                      <jats:sub>mean<\/jats:sub>\n                      of 14.8 mmHg. PHT was present in 26% of patients, hyperdynamic circulation in 5% and PAH in 4%. Patients with advanced fibrosis (METAVIR stage F3\/F4; n=32) had significantly higher CO ( P=0.008), lower SysVR ( P=0.035), higher PAP\n                      <jats:sub>mean<\/jats:sub>\n                      ( P=0.018) and higher pulmonary vascular resistance ( P=0.022) than patients with stage F0\u2013F2 fibrosis ( n=48). Both hyperdynamic circulation and PAH were significantly associated with liver stiffness, fibrosis stage and portal pressure; a non-significant trend was found for CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell counts and HIV RNA levels. No significant changes in PAP\n                      <jats:sub>mean<\/jats:sub>\n                      , CO and SysVR were observed after PEG-IFN-\u03b1+RBV treatment, although a significant decrease in HVPG was noted in patients with HCV eradication ( P=0.013).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The overall prevalence of hyperdynamic circulation and PAH in HIV\u2013HCV coinfection is low. Advanced fibrosis, increased liver stiffness, elevated portal pressure and probably CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell count and HIV viraemia represent risk factors for hyperdynamic circulation and PAH. PHT is present in 26% of HIV\u2013HCV-coinfected patients evaluated for antiviral therapy. Successful HCV eradication significantly decreases HVPG.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp2349","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T05:01:12Z","timestamp":1346821272000},"page":"1327-1334","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["A Prospective Evaluation of Pulmonary, Systemic and Hepatic Haemodynamics in HIV\u2013HCV-Coinfected Patients before and after Antiviral Therapy with Pegylated Interferon and Ribavirin"],"prefix":"10.1177","volume":"17","author":[{"given":"Thomas","family":"Reiberger","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berit A","family":"Payer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnulf","family":"Ferlitsch","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Sieghart","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Breitenecker","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian C","family":"Aichelburg","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Schmied","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Pneumology, Otto-Wagner Hospital, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Rieger","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Peck-Radosavljevic","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Vienna Hepatic Hemodynamic Lab and Vienna HIV & Liver Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,10,1]]},"reference":[{"key":"bibr1-IMP2349","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.11.004"},{"key":"bibr2-IMP2349","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1831"},{"key":"bibr3-IMP2349","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80422-5"},{"key":"bibr4-IMP2349","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01197.x"},{"key":"bibr5-IMP2349","doi-asserted-by":"publisher","DOI":"10.1038\/nm1511"},{"key":"bibr6-IMP2349","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.022"},{"key":"bibr7-IMP2349","doi-asserted-by":"publisher","DOI":"10.3109\/10623320009072210"},{"key":"bibr8-IMP2349","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.15.1632"},{"key":"bibr9-IMP2349","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-005-0313-3"},{"key":"bibr10-IMP2349","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16107-2"},{"key":"bibr11-IMP2349","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.4.1133"},{"key":"bibr12-IMP2349","doi-asserted-by":"publisher","DOI":"10.1177\/135965350801300815"},{"key":"bibr13-IMP2349","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.10.4601"},{"key":"bibr14-IMP2349","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11030554"},{"key":"bibr15-IMP2349","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.3_Supplement.225S"},{"key":"bibr16-IMP2349","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200704-541OC"},{"key":"bibr17-IMP2349","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21431"},{"key":"bibr18-IMP2349","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200538"},{"key":"bibr19-IMP2349","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.1.9"},{"key":"bibr20-IMP2349","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20993"},{"key":"bibr21-IMP2349","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.07.006"},{"key":"bibr22-IMP2349","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2008.00661.x"},{"key":"bibr23-IMP2349","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq518"},{"key":"bibr24-IMP2349","doi-asserted-by":"publisher","DOI":"10.1086\/653214"},{"key":"bibr25-IMP2349","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp297"},{"key":"bibr26-IMP2349","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.03.002"},{"key":"bibr27-IMP2349","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20062"},{"key":"bibr28-IMP2349","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50133"},{"key":"bibr29-IMP2349","first-page":"947","volume":"112","author":"Peck-Radosavljevic M.","year":"2000","journal-title":"Wien Klin Wochenschr"},{"key":"bibr30-IMP2349","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14844-1"},{"key":"bibr31-IMP2349","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00743.x"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:50:59Z","timestamp":1777380659000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP2349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.3851\/IMP2349"],"URL":"https:\/\/doi.org\/10.3851\/imp2349","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}