{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:48:24Z","timestamp":1777452504405,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>HIV lipodystrophy \u2013 characterized by peripheral lipoatrophy, with or without central fat accumulation \u2013 confers increased metabolic risk. However, the functional activity of HIV lipodystrophic tissue in relation to metabolic risk has yet to be fully explored in vivo through the use of non-invasive imaging techniques. This study assesses the relationship between FDG uptake in various fat depots and metabolic\/immune parameters among subjects with HIV lipodystrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Lipodystrophic men on antiretroviral therapy underwent whole-body\n                      <jats:sup>18<\/jats:sup>\n                      F-fluorodeoxyglucose positron emission tomography (FDG-PET)\/computed tomography scans and detailed metabolic\/immune phenotyping.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      FDG uptake in the subcutaneous adipose tissue (SAT) of the extremities (mean standardized uptake value [SUV] of the arm and leg SAT) was found to correlate with the degree of peripheral lipoatrophy ( r=0.7; P=0.01). Extremity SAT FDG uptake was positively associated with homeostasis model assessment of insulin resistance (HOMA-IR; r=0.6; P=0.02) and fasting hyperinsulinaemia ( r=0.7; P=0.01), while fat percentage of extremities was not. Furthermore, extremity SAT FDG uptake was significantly associated with CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell count ( r=0.6; P=0.05). In multivariate modelling for HOMA-IR, extremity SAT FDG uptake remained significant after controlling for body mass index and tumour necrosis factor-\u03b1 (R\n                      <jats:sup>2<\/jats:sup>\n                      for model =0.71, P=0.02; SUV in the extremity SAT \u03b2-estimate 12.3, P=0.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In HIV lipodystrophic patients, extremity SAT FDG uptake is increased in association with reduced extremity fat and may contribute to insulin resistance. Non-invasive assessments of in situ inflammation using FDG-PET may usefully complement histological and gene expression analyses of metabolic dysregulation in peripheral fat among HIV-positive patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp2420","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T12:59:22Z","timestamp":1349441962000},"page":"243-248","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased Fdg Uptake in Association with Reduced Extremity Fat in HIV Patients"],"prefix":"10.1177","volume":"18","author":[{"given":"Martin","family":"Torriani","sequence":"first","affiliation":[{"name":"Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markella V","family":"Zanni","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Fitch","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Stavrou","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam A","family":"Bredella","sequence":"additional","affiliation":[{"name":"Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron M","family":"Cypess","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Grinspoon","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"bibr1-IMP2420","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041811"},{"key":"bibr2-IMP2420","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020794"},{"key":"bibr3-IMP2420","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199911120-00008"},{"key":"bibr4-IMP2420","doi-asserted-by":"publisher","DOI":"10.1086\/655765"},{"key":"bibr5-IMP2420","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200109280-00009"},{"key":"bibr6-IMP2420","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.12.001"},{"key":"bibr7-IMP2420","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90224.2008"},{"key":"bibr8-IMP2420","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00797.2005"},{"key":"bibr9-IMP2420","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00273.2005"},{"key":"bibr10-IMP2420","first-page":"2430","volume":"18","author":"Bleeker-Rovers C.P.","year":"2004","journal-title":"AIDS"},{"key":"bibr11-IMP2420","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2951"},{"key":"bibr12-IMP2420","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.06.004"},{"key":"bibr13-IMP2420","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2005.01.021"},{"key":"bibr14-IMP2420","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.133"},{"key":"bibr15-IMP2420","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-2014-3"},{"key":"bibr16-IMP2420","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1575"},{"key":"bibr17-IMP2420","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.49.29083"},{"key":"bibr18-IMP2420","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00284.2006"},{"key":"bibr19-IMP2420","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200012010-00004"},{"key":"bibr20-IMP2420","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2010.543885"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2420","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:51:11Z","timestamp":1777380671000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP2420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.3851\/IMP2420"],"URL":"https:\/\/doi.org\/10.3851\/imp2420","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}