{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:49:08Z","timestamp":1777452548046,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Tenofovir disoproxil fumarate (TDF) is increasingly used in patients with chronic hepatitis B (CHB) infection. Although associated with renal toxicity in HIV-infected patients, renal dysfunction has been reported rarely in the monoinfected CHB population. To date, TDF-associated Fanconi syndrome has not been reported. Here, we present two cases of TDF-associated Fanconi syndrome with rapid resolution after its cessation. We then discuss risk factors for TDF nephrotoxicity and its implications for screening for renal disease in those patients with CHB monoinfection on TDF, and the use of TDF in at-risk populations.<\/jats:p>","DOI":"10.3851\/imp2649","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T05:51:56Z","timestamp":1373435516000},"page":"945-948","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":67,"title":["Tenofovir-Associated Fanconi Syndrome in Patients with Chronic Hepatitis B Monoinfection"],"prefix":"10.1177","volume":"18","author":[{"given":"David M","family":"Gracey","sequence":"first","affiliation":[{"name":"Renal Unit, Royal Prince Alfred Hospital, Sydney, Australia"},{"name":"Central Clinical School, Faculty of Medicine, University of Sydney, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Snelling","sequence":"additional","affiliation":[{"name":"Renal Unit, Royal Prince Alfred Hospital, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Central Clinical School, Faculty of Medicine, University of Sydney, Sydney, Australia"},{"name":"Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone I","family":"Strasser","sequence":"additional","affiliation":[{"name":"Central Clinical School, Faculty of Medicine, University of Sydney, Sydney, Australia"},{"name":"AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"bibr1-IMP2649","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051871"},{"key":"bibr2-IMP2649","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06545.x"},{"key":"bibr3-IMP2649","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23190"},{"key":"bibr4-IMP2649","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.10.001"},{"key":"bibr5-IMP2649","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9080-3"},{"key":"bibr6-IMP2649","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328345ef5e"},{"key":"bibr7-IMP2649","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182100f59"},{"key":"bibr8-IMP2649","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.01.022"},{"key":"bibr9-IMP2649","first-page":"299","volume":"147","author":"Fanconi G.","year":"1936","journal-title":"Jahrb Kinderheilkd"},{"key":"bibr10-IMP2649","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22885"},{"key":"bibr11-IMP2649","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05093.x"},{"key":"bibr12-IMP2649","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00350-08"},{"key":"bibr13-IMP2649","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2012.01602.x"},{"key":"bibr14-IMP2649","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.03.030"},{"issue":"1","key":"bibr15-IMP2649","doi-asserted-by":"crossref","first-page":"262A","DOI":"10.1002\/hep.24352","volume":"54","author":"Lampertico P.","year":"2011","journal-title":"Hepatology"},{"key":"bibr16-IMP2649","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00866.x"},{"key":"bibr17-IMP2649","doi-asserted-by":"publisher","DOI":"10.1086\/430257"},{"key":"bibr18-IMP2649","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9080-3"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2649","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:51:29Z","timestamp":1777380689000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP2649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.3851\/IMP2649"],"URL":"https:\/\/doi.org\/10.3851\/imp2649","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}