{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:38:32Z","timestamp":1791952712010,"version":"4.3.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Loss to follow-up (LTFU) in HIV-positive cohorts is an important surrogate for interrupted clinical care, which can potentially influence the assessment of HIV disease status and outcomes. After preliminary evaluation of LTFU rates and patient characteristics, we evaluated the risk of mortality by LTFU status in a high-resource setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rates of LTFU were measured in the Australian HIV Observational Database for a range of patient characteristics. Multivariate repeated measures regression methods were used to identify determinants of LTFU. Mortality by LTFU status was ascertained using linkage to the National Death Index. Survival following combination antiretroviral therapy initiation was investigated using the Kaplan\u2013Meier (KM) method and Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 3,413 patients included in this analysis, 1,632 (47.8%) had at least one episode of LTFU after enrolment. Multivariate predictors of LTFU included viral load (VL)&gt;10,000 copies\/ml (rate ratio [RR] 1.63; 95% CI 1.45, 1.84; ref \u2264400), time under follow-up (per year; RR 1.03; 95% CI 1.02, 1.04) and prior LTFU (per episode; RR 1.15; 95% CI 1.06, 1.24). KM curves for survival were similar by LTFU status ( P=0.484). LTFU was not associated with mortality in Cox proportional hazards models (univariate hazard ratio [HR] 0.93; 95% CI 0.69, 1.26) and multivariate HR 1.04 (95% CI 0.77, 1.43).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased risk of LTFU was identified amongst patients with potentially higher infectiousness. We did not find significant mortality risk associated with LTFU. This is consistent with timely re-engagement with treatment, possibly via high levels of unreported linkage to other health-care providers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp2916","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T06:50:25Z","timestamp":1415343025000},"page":"731-741","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Loss to follow-up in the Australian HIV Observational Database"],"prefix":"10.1177","volume":"20","author":[{"given":"Hamish","family":"McManus","sequence":"first","affiliation":[{"name":"The Kirby Institute, UNSW Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Petoumenos","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Brown","sequence":"additional","affiliation":[{"name":"Illawarra Sexual Health Service, Warrawong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Baker","sequence":"additional","affiliation":[{"name":"East Sydney Doctors, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Russell","sequence":"additional","affiliation":[{"name":"Cairns Sexual Health Service, Cairns, Australia"},{"name":"James Cook University, Cairns, Australia"},{"name":"The University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Read","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Smith","sequence":"additional","affiliation":[{"name":"The Albion Centre, Sydney, Australia"},{"name":"School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Wray","sequence":"additional","affiliation":[{"name":"Sydney Sexual Health Centre, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Giles","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Monash Medical Centre, Melbourne, Australia"},{"name":"Department of Infectious Diseases, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hoy","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Alfred Hospital and Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Carr","sequence":"additional","affiliation":[{"name":"HIV, Immunology and Infectious Diseases Unit, St Vincent's Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G","family":"Law","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Australian HIV Observational Database","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"key":"bibr1-IMP2916","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005790"},{"key":"bibr2-IMP2916","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31815b833a"},{"key":"bibr3-IMP2916","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2652-13-49"},{"key":"bibr4-IMP2916","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000390"},{"key":"bibr5-IMP2916","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102305"},{"key":"bibr6-IMP2916","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2013.0073"},{"key":"bibr7-IMP2916","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2008.00678.x"},{"key":"bibr8-IMP2916","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.12.007"},{"key":"bibr9-IMP2916","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2008.00557.x"},{"key":"bibr10-IMP2916","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199910010-00018"},{"key":"bibr11-IMP2916","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328353f38e"},{"key":"bibr12-IMP2916","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2010000700022"},{"key":"bibr13-IMP2916","first-page":"631","volume":"57","author":"Centers for Disease Control and Prevention.","year":"2008","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr14-IMP2916","doi-asserted-by":"publisher","DOI":"10.1086\/522550"},{"key":"bibr15-IMP2916","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32831de90b"},{"key":"bibr16-IMP2916","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030218"},{"key":"bibr17-IMP2916","doi-asserted-by":"publisher","DOI":"10.1177\/0956462412472812"},{"key":"bibr18-IMP2916","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2006.00357.x"},{"key":"bibr19-IMP2916","doi-asserted-by":"publisher","DOI":"10.1071\/SH07082"},{"key":"bibr20-IMP2916","unstructured":"Kirby Institute. Australian HIV Observational Database Annual Report 2013. (Accessed 6 June 2014.) Available from https:\/\/kirby.unsw.edu.au\/sites\/default\/files\/hiv\/attachment\/AHOD-Report-Sept2013.pdf."},{"key":"bibr21-IMP2916","doi-asserted-by":"publisher","DOI":"10.1093\/sw\/42.6.541"},{"key":"bibr22-IMP2916","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-011-0414-4"},{"key":"bibr23-IMP2916","doi-asserted-by":"publisher","DOI":"10.1086\/313849"},{"key":"bibr24-IMP2916","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-011-9971-5"},{"key":"bibr25-IMP2916","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis401"},{"key":"bibr26-IMP2916","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.03.014"},{"key":"bibr27-IMP2916","doi-asserted-by":"publisher","DOI":"10.2307\/3038307"},{"key":"bibr28-IMP2916","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8292(99)00028-3"},{"key":"bibr29-IMP2916","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2010.525609"},{"key":"bibr30-IMP2916","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-007-9238-3"},{"key":"bibr31-IMP2916","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60743-X"},{"key":"bibr32-IMP2916","unstructured":"Australasian Society for HIV Medicine. 2013 Antiretroviral Guidelines with Australian Commentary 2014. (Updated 2 December 2013. Accessed 11 March 2014.) Available from http:\/\/arv.ashm.org.au\/arv-guidelines\/initiating-art-in-treatment-naive-patients."},{"key":"bibr33-IMP2916","unstructured":"Australian Government Department of Human Services. Highly Specialised Drugs (HSD) program: Commonwealth of Australia; 2014. (Updated 19 December 2013. Accessed 12 May 2014.) Available from http:\/\/www.medicareaustralia.gov.au\/provider\/pbs\/highly-specialised-drugs\/#N100E3."},{"key":"bibr34-IMP2916","unstructured":"Australian Government Department of Health. Browse by Section 100 Item List: Highly Specialised Drugs program; 2014. (Accessed 12 May 2014.) Available from http:\/\/pbs.gov.au\/browse\/section100-hb?initial=a."}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2916","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:52:21Z","timestamp":1777380741000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP2916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,1]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.3851\/IMP2916"],"URL":"https:\/\/doi.org\/10.3851\/imp2916","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,1]]}}}