{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:47:37Z","timestamp":1790192857250,"version":"4.1.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In a context of controversy about influenza antiviral treatments, this study assessed primary healthcare physicians\u2019 prescription of neuraminidase inhibitors (NIs) in France during pandemic and seasonal influenza between 2009 and 2013.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational study, using data recorded in three national databases, estimated the rate of NI prescription among influenza-like illness (ILI) patients seen in GP and paediatrician consultations, and determined factors associated with this prescription according to a multivariate analysis. NI delivery by pharmacists was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Rates of NI prescription were estimated to be 61.1% among ILI patients with a severe influenza risk factor seen in GP consultation during the A(H1N1)pdm2009 pandemic versus an average rate of 25.9% during the three following seasonal influenza epidemics. Factors associated with NI prescription were a chronic disease in patients under 65 years (OR 14.85; 95% CI 13.00, 16.97) and in those aged 65 and older (OR 7.54; 5.86, 9.70), an age \u226565 years in patients without chronic disease (OR 1.35; 1.04, 1.74), a pregnancy (OR 10.63; 7.67, 15.76), obesity (OR 4.67; 3.50, 6.22) and a consultation during the pandemic A(H1N1)pdm2009 (OR 3.19; 2.93, 3.48). The number of antiviral treatments delivered by pharmacists during the A(H1N1)pdm2009 pandemic was 835 per 100,000 inhabitants, and an average of 275 per 100,000 inhabitants during the three following seasonal influenza epidemics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although physicians seem to follow the recommended indications for NIs in primary health-care practice, this study confirms the low rate of NI prescription to ILI patients with a severe influenza risk factor, especially during seasonal epidemics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp2945","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T07:04:07Z","timestamp":1424156647000},"page":"753-761","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of Neuraminidase Inhibitors in Primary Health Care during Pandemic and Seasonal Influenza between 2009 and 2013"],"prefix":"10.1177","volume":"20","author":[{"given":"Thierry","family":"Blanchon","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S 1136, Paris, France"},{"name":"INSERM, UMR_S 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9licit\u00e9","family":"Geffrier","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S 1136, Paris, France"},{"name":"INSERM, UMR_S 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Turbelin","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S 1136, Paris, France"},{"name":"INSERM, UMR_S 1136, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Daviaud","sequence":"additional","affiliation":[{"name":"R\u00e9seau des Groupes R\u00e9gionaux d'Observation de la Grippe (GROG), Coordination nationale, & Open Rome, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Laou\u00e9nan","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Bichat, Unit\u00e9 de Biostatistiques, Paris, France"},{"name":"Sorbonne Universit\u00e9s, Univ Paris Diderot, UMR_S 1137, Paris, France"},{"name":"INSERM UMR_S 1137, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Duval","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, Univ Paris Diderot, UMR_S 1137, Paris, France"},{"name":"INSERM UMR_S 1137, Paris, France"},{"name":"APHP, INSERM, CIC 007, H\u00f4pital Bichat, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lambert","sequence":"additional","affiliation":[{"name":"IMS-Health, Puteaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hanslik","sequence":"additional","affiliation":[{"name":"INSERM, UMR_S 1136, Paris, France"},{"name":"APHP, Service de m\u00e9decine interne, h\u00f4pital Ambroise-Par\u00e9, Boulogne-Billancourt, France"},{"name":"UFR des sciences de la sant\u00e9 Simone-Veil, Universit\u00e9 de Versailles - Saint-Quentin-en-Yvelines, Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Mosnier","sequence":"additional","affiliation":[{"name":"R\u00e9seau des Groupes R\u00e9gionaux d'Observation de la Grippe (GROG), Coordination nationale, & Open Rome, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Leport","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, Univ Paris Diderot, UMR_S 1137, Paris, France"},{"name":"INSERM UMR_S 1137, Paris, France"},{"name":"APHP, Unit\u00e9 de Coordination des Risques Epid\u00e9miques et Biologiques, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"key":"bibr1-IMP2945","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.81.1.97"},{"key":"bibr2-IMP2945","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065919"},{"key":"bibr3-IMP2945","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045051"},{"key":"bibr4-IMP2945","first-page":"487","volume":"18","author":"L\u00e9ophonte P.","year":"2001","journal-title":"Rev Mal Respir"},{"key":"bibr5-IMP2945","first-page":"129","volume":"14","author":"Haut Conseil de la Sant\u00e9 Publique (France).","year":"2013","journal-title":"Bull Epid\u00e9miol Hebd"},{"key":"bibr6-IMP2945","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70295-X"},{"key":"bibr7-IMP2945","first-page":"CD004876","volume":"2","author":"Jefferson T.","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr8-IMP2945","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.09.063"},{"key":"bibr9-IMP2945","volume-title":"[On the use of influenza antivirals in patients outside of the hospital for curative treatment and post-exposure treatment during circulation of seasonal influenza virus]","author":"Haut Conseil de la Sant\u00e9 Publique (France).","year":"2012"},{"key":"bibr10-IMP2945","volume-title":"Seasonal Influenza (Flu) - 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