{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:01:08Z","timestamp":1790316068492,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In HIV\u2013HBV-coinfected patients from sub-Saharan Africa, incidence of antiviral resistant HBV-mutations after initiating long-term antiretroviral therapy (ART) has only been evaluated in limited patient populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this nested, prospective cohort study from two randomized controlled trials in C\u00f4te d'Ivoire, 168 ART-naive HIV\u2013HBV-coinfected patients, starting lamivudine (LAM, n=82) or tenofovir\/emtricitabine (TDF\/FTC, n=86) containing ART were included. HBV DNA viral load (VL) was quantified using an in-house assay (detection limit: &lt;12 copies\/ml) while pol and preS\/S regions of positive samples were sequenced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At ART-initiation, 39 (23.2%) were hepatitis B e antigen-positive, 53 (31.5%) had alanine or aspartate aminotransferase levels &gt;40 IU\/ml and 98\/100 (98.0%) harboured genotype E. Among the 127 (75.6%) patients with detectable baseline HBV VL (median 4.27 log\n                      <jats:sub>10<\/jats:sub>\n                      copies\/ml, IQR 3.14\u20137.64), cumulative percentage achieving undetectable HBV DNA was 74.2% for patients undergoing LAM-containing ART and 94.2% for TDF\/FTC-containing ART after a median 35.5 months (IQR 24.3-36.5). No baseline antiviral resistance mutations were observed. Among 28\/127 (22.1%) patients with low-level persistent viraemia (last HBV VL: between 12 to &lt;10\n                      <jats:sup>5<\/jats:sup>\n                      copies\/ml), no incident amino acid changes associated with antiviral resistance were observed. Among 11\/127 (8.7%) patients with high-level persistent viraemia (last HBV VL: \u226510\n                      <jats:sup>5<\/jats:sup>\n                      copies\/ml), only two harboured incident LAM-resistance mutations at positions rtV173L+rtL180M+rtM204V with no patient exhibiting TDF\/FTC-resistance. Two patients had transaminase fares &gt;120 IU\/ml (incidence rate =0.5\/100 person-years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Antiviral resistance, particularly to LAM, was remarkably rare in this cohort of HIV-HBV-coinfected patients. Further research is needed to determine which coinfected populations might benefit from LAM-containing ART with low risk of resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp2959","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T06:35:47Z","timestamp":1428474947000},"page":"643-654","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Low Risk of Lamivudine-Resistant HBV and Hepatic Fares in Treated HIV\u2013HBV-Coinfected Patients from C\u00f4te d'Ivoire"],"prefix":"10.1177","volume":"20","author":[{"given":"Anders","family":"Boyd","sequence":"first","affiliation":[{"name":"INSERM, UMR_S1136, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Moh","sequence":"additional","affiliation":[{"name":"Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, C\u00f4te d'Ivoire"},{"name":"Department of Infectious and Tropical Diseases, Treichville University Teaching Hospital, Abidjan, C\u00f4te d'Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Gabillard","sequence":"additional","affiliation":[{"name":"INSERM, U897, Epid\u00e9miologie-Biostatistique, Bordeaux, France"},{"name":"University of Bordeaux, ISPED, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me le","family":"Carrou","sequence":"additional","affiliation":[{"name":"Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, C\u00f4te d'Ivoire"},{"name":"INSERM, U897, Epid\u00e9miologie-Biostatistique, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Danel","sequence":"additional","affiliation":[{"name":"Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, C\u00f4te d'Ivoire"},{"name":"INSERM, U897, Epid\u00e9miologie-Biostatistique, Bordeaux, France"},{"name":"University of Bordeaux, ISPED, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Anglaret","sequence":"additional","affiliation":[{"name":"Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, C\u00f4te d'Ivoire"},{"name":"INSERM, U897, Epid\u00e9miologie-Biostatistique, Bordeaux, France"},{"name":"University of Bordeaux, ISPED, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge P","family":"Eholi\u00e9","sequence":"additional","affiliation":[{"name":"Programme PAC-CI, ANRS Research Site, Treichville University Hospital, Abidjan, C\u00f4te d'Ivoire"},{"name":"Department of Infectious and Tropical Diseases, Treichville University Teaching Hospital, Abidjan, C\u00f4te d'Ivoire"},{"name":"Medical School, University Felix Houphouet Boigny, Abidjan, C\u00f4te d'Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Maylin","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, H\u00f4pital Saint-Louis, AP-HP, Paris, France"},{"name":"Universit\u00e9 Paris-Diderot, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Delaugerre","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, H\u00f4pital Saint-Louis, AP-HP, Paris, France"},{"name":"Universit\u00e9 Paris-Diderot, Paris, France"},{"name":"INSERM U941, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Zoulim","sequence":"additional","affiliation":[{"name":"Centre de Recherche sur le Cancer de Lyon, Equipes 15 et 16, INSERM, Unit\u00e9 1052, CNRS, UMR 5286, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Marie","family":"Girard","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases, Saint-Antoine Hospital, AP-HP, Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Lacombe","sequence":"additional","affiliation":[{"name":"Department of Infectious and Tropical Diseases, Saint-Antoine Hospital, AP-HP, Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ANRS 12240 VarBVA study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"bibr1-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833a0918"},{"key":"bibr2-IMP2959","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62001-6"},{"key":"bibr3-IMP2959","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.11.018"},{"key":"bibr4-IMP2959","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis432"},{"key":"bibr5-IMP2959","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.036"},{"key":"bibr6-IMP2959","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70314-0"},{"key":"bibr7-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000218550.85081.59"},{"key":"bibr8-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182a60f7d"},{"key":"bibr9-IMP2959","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1911"},{"key":"bibr10-IMP2959","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20974"},{"key":"bibr11-IMP2959","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks333"},{"key":"bibr12-IMP2959","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01466.x"},{"key":"bibr13-IMP2959","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-4-561"},{"key":"bibr14-IMP2959","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059346"},{"key":"bibr15-IMP2959","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00049-5"},{"key":"bibr16-IMP2959","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22796"},{"key":"bibr17-IMP2959","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1499"},{"key":"bibr18-IMP2959","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26374"},{"key":"bibr19-IMP2959","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68887-9"},{"key":"bibr20-IMP2959","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit470"},{"key":"bibr21-IMP2959","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.6.2709-2717.2005"},{"key":"bibr22-IMP2959","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27182"},{"key":"bibr23-IMP2959","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.865"},{"key":"bibr24-IMP2959","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00098.x"},{"key":"bibr25-IMP2959","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20545"},{"key":"bibr26-IMP2959","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21588"},{"key":"bibr27-IMP2959","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24038"},{"key":"bibr28-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3180314b46"},{"key":"bibr29-IMP2959","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300525"},{"key":"bibr30-IMP2959","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.12.030"},{"key":"bibr31-IMP2959","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.063"},{"key":"bibr32-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32836011c2"},{"key":"bibr33-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835a9984"},{"key":"bibr34-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328349bbf3"},{"key":"bibr35-IMP2959","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2942"},{"key":"bibr36-IMP2959","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.2747"},{"key":"bibr37-IMP2959","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu630"},{"key":"bibr38-IMP2959","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(12)60012-9"},{"key":"bibr39-IMP2959","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp414"},{"key":"bibr40-IMP2959","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70135-4"},{"key":"bibr41-IMP2959","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.03.037"},{"key":"bibr42-IMP2959","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22462"},{"key":"bibr43-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283410ccb"},{"key":"bibr44-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000084"},{"key":"bibr45-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328334bddb"},{"key":"bibr46-IMP2959","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit002"},{"key":"bibr47-IMP2959","doi-asserted-by":"publisher","DOI":"10.1086\/593104"},{"key":"bibr48-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835cb9c8"},{"key":"bibr49-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000126"},{"key":"bibr50-IMP2959","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000216"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2959","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2959","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:52:19Z","timestamp":1777380739000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP2959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,1]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.3851\/IMP2959"],"URL":"https:\/\/doi.org\/10.3851\/imp2959","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,1]]}}}