{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:54:01Z","timestamp":1777452841712,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>We report a case of acute cytomegalovirus (CMV) infection with positive HEV and Epstein\u2013Barr virus (EBV) serology. No patients have been reported positive for immunoglobulin (Ig)M antibodies to all three viruses. This patient had progressively increasing titres of IgM antibody for CMV, HEV and EBV. Only CMV DNA was detectable before antiviral treatment. After antiviral treatment, the patient recovered completely. At day 180 the CMV IgG test had converted to positive with CMV IgM (+), EBV IgM (-) and HEV IgM (-). Our report indicates that dependence upon serology alone is unreliable in the diagnosis of acute CMV, EBV and HEV infections. The diagnosis of CMV, HEV and EBV should be based on a combination of clinical features, serology and confirmatory PCR testing.<\/jats:p>","DOI":"10.3851\/imp2991","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T06:53:48Z","timestamp":1442472828000},"page":"171-173","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute Viral Hepatitis Presenting as Cytomegalovirus, Hepatitis E and Epstein-Barr virus IgM Antibody Positive"],"prefix":"10.1177","volume":"21","author":[{"given":"Qin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Infectious Disease, Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The Third Affiliated Hospital of Sun-Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiyun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Yan","sequence":"additional","affiliation":[{"name":"Scientific Research Center, Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathogen Diagnosis and Biosafety, Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Scientific Research Center, Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunwen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathogen Diagnosis and Biosafety, Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hepatology Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,2,1]]},"reference":[{"key":"bibr1-IMP2991","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872010001100016"},{"key":"bibr2-IMP2991","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.03.004"},{"key":"bibr3-IMP2991","first-page":"349","volume":"62","author":"Olson D.","year":"2009","journal-title":"S D Med"},{"key":"bibr4-IMP2991","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.05.022"},{"key":"bibr5-IMP2991","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32832f5be4"},{"key":"bibr6-IMP2991","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23827"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP2991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:52:27Z","timestamp":1777380747000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP2991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,1]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.3851\/IMP2991"],"URL":"https:\/\/doi.org\/10.3851\/imp2991","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,1]]}}}