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We suggest that in our patients the prompt clearance of HCV following direct-acting antivirals leads to a paradoxical effect on the innate and adaptive immune system mediating the reactivation of herpetic infection.<\/jats:p>","DOI":"10.3851\/imp3072","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T09:28:04Z","timestamp":1470648484000},"page":"739-742","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Herpes virus Reactivation after Initiation of Interferon-Free Antiviral Agents in HIV\u2013HCV-Coinfected Subjects: A New Immune Restoration Disease?"],"prefix":"10.1177","volume":"21","author":[{"given":"Raffaella","family":"Marocco","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Lichtner","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Tieghi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Pozzetto","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio M","family":"Mastroianni","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Public Health and Infectious Diseases, Sapienza University, Polo Pontino, Latina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"bibr1-IMP3072","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000182"},{"key":"bibr2-IMP3072","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059302"},{"key":"bibr3-IMP3072","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00703-3"},{"key":"bibr4-IMP3072","doi-asserted-by":"publisher","DOI":"10.1258\/0956462054308404"},{"key":"bibr5-IMP3072","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67714"},{"key":"bibr6-IMP3072","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119568"},{"key":"bibr7-IMP3072","doi-asserted-by":"publisher","DOI":"10.1086\/515019"},{"key":"bibr8-IMP3072","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00015-09"},{"key":"bibr9-IMP3072","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12465"},{"key":"bibr10-IMP3072","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.03.004"},{"key":"bibr11-IMP3072","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv391"},{"key":"bibr12-IMP3072","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.05.016"},{"key":"bibr13-IMP3072","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.003"},{"key":"bibr14-IMP3072","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.05.026"},{"key":"bibr15-IMP3072","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.02.026"},{"key":"bibr16-IMP3072","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ474"},{"key":"bibr17-IMP3072","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12578"},{"key":"bibr18-IMP3072","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.06.023"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:52:05Z","timestamp":1777380725000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP3072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,1]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.3851\/IMP3072"],"URL":"https:\/\/doi.org\/10.3851\/imp3072","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,1]]}}}