{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:51:12Z","timestamp":1777452672912,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Renal toxicity is a common side effect during tenofovir (TDF)-use in HIV-infected, but not necessarily HBV-infected, patients. Nevertheless, little is known regarding TDF-use on renal impairment during HIV\u2013HBV coinfection. We aimed to evaluate the progression and determinants of renal impairment in coinfected patients undergoing TDF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 175 coinfected patients initiating TDF-containing antiretroviral therapy were prospectively followed. Estimated glomerular filtration rates (eGFR) were calculated at baseline and every 6\u201312 months. Determinants of eGRF change from baseline (\u0394eGFR) were evaluated using mixed-effect linear regression and progression towards renal impairment using proportional-hazards regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, average eGFR was 96.7 ml\/min per 1.73m\n                      <jats:sup>2<\/jats:sup>\n                      (95% CI 93.8, 99.6). During a median 58.3 months (IQR 33.7\u201392.1) of treatment, eGFR decreased a monthly average of -0.14 ml\/min per 1.73m\n                      <jats:sup>2<\/jats:sup>\n                      (95% CI -0.16, -0.12). Significantly faster \u0394eGFR was associated with baseline eGFR&gt;90 ( P=0.002), male gender ( P=0.04), previous AIDS-defining illness at baseline ( P=0.03), baseline liver cirrhosis ( P=0.03) and concomitant protease inhibitor use ( P=0.005). Between respective baseline and end of follow-up visits, the proportion of patients with renal impairment increased: normal function, 65.7% to 53.1%; mild impairment, 32.6% to 40.0%; moderate impairment, 1.7% to 6.9%. Higher age ( P=0.01) and previous AIDS-defining illness ( P=0.02) at baseline were independent risk-factors for developing impairment, while undetectable HBV DNA on-treatment was protective ( P=0.006). Five (2.9%) patients permanently discontinued TDF after a renal event.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Severe HIV-related and HBV-related morbidity negatively affects renal function in coinfected patients undergoing long-term TDF. Although most patients only developed mild\/moderate impairment, close renal monitoring is warranted for this particular population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp3076","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T06:28:05Z","timestamp":1472020085000},"page":"31-42","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Renal Outcomes after up to 8 Years of Tenofovir Exposure in HIV\u2013HBV-Coinfected Patients"],"prefix":"10.1177","volume":"22","author":[{"given":"Anders","family":"Boyd","sequence":"first","affiliation":[{"name":"INSERM, UMR_S1136, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Miailhes","sequence":"additional","affiliation":[{"name":"Centre de Recherche sur le Cancer de Lyon, Equipes 15 et 16, INSERM, Unit\u00e9 1052, CNRS, UMR 5286, Lyon, France"},{"name":"Service des Maladies Infectieuses et Tropicales, H\u00f4pital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Lascoux-Combe","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, H\u00f4pital Saint-Louis, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayette","family":"Rougier","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, H\u00f4pital Saint-Antoine, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Marie","family":"Girard","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, H\u00f4pital Saint-Antoine, AP-HP, Paris, France"},{"name":"Sorbonne Universit\u00e9s, INSERM, UPMC Univ Paris 06, Institut Pierre Louis d'\u00e9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP UMRS 1136), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Plaisier","sequence":"additional","affiliation":[{"name":"INSERM, UMR_S 1155, Paris, France"},{"name":"Service de N\u00e9phrologie et Dialyses, H\u00f4pital Tenon, AP-HP, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Lacombe","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, H\u00f4pital Saint-Antoine, AP-HP, Paris, France"},{"name":"Sorbonne Universit\u00e9s, INSERM, UPMC Univ Paris 06, Institut Pierre Louis d'\u00e9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP UMRS 1136), Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"bibr1-IMP3076","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302062"},{"key":"bibr2-IMP3076","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22884"},{"key":"bibr3-IMP3076","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.016"},{"key":"bibr4-IMP3076","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27182"},{"key":"bibr5-IMP3076","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit043"},{"key":"bibr6-IMP3076","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328357f5ed"},{"key":"bibr7-IMP3076","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu617"},{"key":"bibr8-IMP3076","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.11.021"},{"key":"bibr9-IMP3076","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu734"},{"key":"bibr10-IMP3076","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.08.045"},{"key":"bibr11-IMP3076","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01084.x"},{"key":"bibr12-IMP3076","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12088"},{"key":"bibr13-IMP3076","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000795"},{"key":"bibr14-IMP3076","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50319"},{"key":"bibr15-IMP3076","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.01.022"},{"key":"bibr16-IMP3076","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2010.01275.x"},{"key":"bibr17-IMP3076","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"bibr18-IMP3076","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-11-201306040-00007"},{"key":"bibr19-IMP3076","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1832"},{"key":"bibr20-IMP3076","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1177\/135965350701200812","volume":"12","author":"Fux 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