{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:51:42Z","timestamp":1777452702898,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>We report two patients who had taken levothyroxine at the same dose for several years and who had stable thyroid stimulating hormone (TSH) levels, and who developed clinical and biological hyperthyroidism following switch from ritonavir-boosted protease inhibitors (PIs) to dolutegravir-based HAART. Levothyroxine is metabolized by deiodination and glucuronidation and the induction of glucuronidation by ritonavir leads to an increased elimination of levothyroxine and a necessity of higher daily doses. Patients who switch from ritonavir-boosted PIs to antiretroviral drugs-based HAART with minimal drug-interaction such as dolutegravir, may require an adjustment in their dose of levothyroxine in order to prevent hyperthyroidism due to impaired elimination of levothyroxine without ritonavir.<\/jats:p>","DOI":"10.3851\/imp3107","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T11:47:49Z","timestamp":1478864869000},"page":"271-272","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Early Neuropsychological Adverse Events after Switching from PI\/r to Dolutegravir Could be Related to Hyperthyroidism in Patients under Levothyroxine"],"prefix":"10.1177","volume":"22","author":[{"given":"Jean-Luc","family":"Berger","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, Reims Teaching Hospitals, Robert Debr\u00e9 Hospital, Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, Reims Teaching Hospitals, Robert Debr\u00e9 Hospital, Reims, France"},{"name":"Faculty of Medicine, University of Reims Champagne-Ardenne, EA-4684, \/ SFR CAP-SANTE, Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Lebrun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, Reims Teaching Hospitals, Robert Debr\u00e9 Hospital, Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Migault","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, Reims Teaching Hospitals, Robert Debr\u00e9 Hospital, Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Hentzien","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, Reims Teaching Hospitals, Robert Debr\u00e9 Hospital, Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Marty","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Reims University Hospital, 51095, Reims Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firouz\u00e9","family":"Bani-Sadr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, Reims Teaching Hospitals, Robert Debr\u00e9 Hospital, Reims, France"},{"name":"Faculty of Medicine, University of Reims Champagne-Ardenne, EA-4684, \/ SFR CAP-SANTE, Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,4,1]]},"reference":[{"key":"bibr1-IMP3107","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12205"},{"key":"bibr2-IMP3107","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000226969.96880.3c"},{"key":"bibr3-IMP3107","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215541"},{"key":"bibr4-IMP3107","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000790"},{"key":"bibr5-IMP3107","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.016097"},{"key":"bibr6-IMP3107","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H423"},{"key":"bibr7-IMP3107","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00292-13"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:52:10Z","timestamp":1777380730000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP3107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,1]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.3851\/IMP3107"],"URL":"https:\/\/doi.org\/10.3851\/imp3107","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,1]]}}}