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The patient was successfully treated with acyclovir but presented sequelae of encephalitis. Here we discuss the possible role of low-dose methotrexate therapy as a risk factor of neurological herpes reactivation and severe disease. The host-related and viral risk factors are also addressed.<\/jats:p>","DOI":"10.3851\/imp3110","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T10:35:58Z","timestamp":1479897358000},"page":"357-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Herpes Simplex Type 2 Encephalitis and Methotrexate Medication: A Fortuitous or Causative Association in a Patient with Spondyloarthritis?"],"prefix":"10.1177","volume":"22","author":[{"given":"Julien","family":"Lupo","sequence":"first","affiliation":[{"name":"Laboratory of Virology, University Hospital of Grenoble, Grenoble, France"},{"name":"Institut de Biologie Structurale, CEA, CNRS, University Grenoble Alpes, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oph\u00e9lie Dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University 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