{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:52:43Z","timestamp":1777452763341,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To investigate the association between inosine triphosphatase (ITPase) activity and the degree of anaemia occurring during direct-acting antiviral (DAA)\/ribavirin (RBV)-based therapy in patients with cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a multicentre, prospective study 227 patients with HCV-related cirrhosis treated with DAA and RBV were enrolled. All patients were screened for the rs1127354 and rs7270101 ITPA single nucleotide polymorphisms using direct sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>150 (66.1%) patients had normal (100%) ITPase activity, 48 (21.1%) had moderate (60%) activity and 29 (12.8%) minimal (\u226430%) activity. The ITPase activity significantly influenced the haemoglobin concentration: at day 15 it was -1.248 (sd \u00b10.978) in the 150 patients with an ITPase activity of 100% and -0.616 (\u00b10.862) in the 77 patients with an ITPase activity less than 100% ( P &lt;0.000), and at day 30 it was -1.941 \u00b11.218 versus -1.11 \u00b11.218 ( P &lt;0.000). The 63 patients with a severe (at least 3\/dl) haemoglobin decline, compared to those without, more frequently had an ITPase activity of 100% (82.1% versus 62.8%; P=0.021), were older (mean age \u00b1sd: 66.7 \u00b18.2 versus 61.4 \u00b19.7 years; P=0.004) and were treated with a higher ribavirin dose (13.7 \u00b12.1 versus 12.8 \u00b12.5 mg\/ kg\/day; P=0.008). At multivariate logistic regression analysis, the ITPase activity of 100% (OR: 2.83; 95% CI: 1.12, 7.10), male gender (OR: 3.22; 95% CI: 1.35, 7.66), body mass index (OR: 1.17; 95% CI: 1.03, 1.34) and dose of ribavirin (OR: 1.22; 95% CI: 1.06, 1.47) were independent predictors of a severe decline in haemoglobin ( P&lt;0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that the polymorphisms in the ITPA gene influence the severity of anaemia during the first month of a DAA\/RBV-based treatment in HCV-related cirrhosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp3134","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T10:17:41Z","timestamp":1486376261000},"page":"551-558","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["ITPase Activity Modulates the Severity of Anaemia in HCV-Related Cirrhosis Treated with Ribavirin-Containing Interferon-Free Regimens"],"prefix":"10.1177","volume":"22","author":[{"given":"Nicola","family":"Coppola","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"De Pascalis","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Messina","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, AO Caserta, Caserta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Di Caprio","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, AO Caserta, Caserta, Italy"},{"name":"HIV Unit, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Martini","sequence":"additional","affiliation":[{"name":"HIV Unit, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"De Stefano","sequence":"additional","affiliation":[{"name":"IX Interventional Ultrasound Unit for Infectious Diseases, AORN dei Colli, P.O. Cotugno, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Starace","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranca","family":"Stornaiuolo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Stanzione","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Ascione","sequence":"additional","affiliation":[{"name":"IX Interventional Ultrasound Unit for Infectious Diseases, AORN dei Colli, P.O. 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