{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:30:00Z","timestamp":1790206200211,"version":"4.1.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We examined whether waist circumference (WC) and self-reported abdominal size changes can estimate visceral adipose tissue (VAT) changes for those initiating antiretroviral therapy (ART).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospectively collected data from ACTG A5257 and its metabolic substudy, A5260s, were used for this analysis. ART-naive HIV-infected participants were randomized to one of three contemporary ART regimens. Changes in abdominal CT-measured VAT and total adipose tissue (TAT) and DXA-measured trunk fat were tested for association with WC changes (by Pearson correlation) and categories of self-reported abdominal size changes (by ANOVA) between entry and week 96. Linear models compared WC and self-reported changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study population ( n=328) was predominantly male (90%) and White non-Hispanic (44%) with a baseline median age of 36 years and body mass index of 25 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . At week 96, median WC change was +2.8 cm. Of those reporting at week 96, 53% indicated \u2018no change\/lost\u2019, 39% \u2018gained some\/somewhat larger\u2019 and 8% \u2018gained a lot\/much larger\u2019 as their self-reported changes. Trunk fat, VAT and TAT changes differed across self-reported groups (ANOVA P&lt;0.0001 for all), and the group ordering was as expected. WC changes were strongly correlated with CT and DXA changes (trunk fat: \u03c1=0.72, p&lt;0.0001; VAT: \u03c1=0.52, p&lt;0.0001; TAT: \u03c1=0.62, p&lt;0.0001). While WC changes explained a greater proportion of VAT, TAT and trunk fat variation, self-reported changes remained a significant predictor after controlling for WC (p&lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WC and self-reported abdominal changes each correlated directly with imaging-derived abdominal fat measures, and can be used as reliable, affordable tools for central adiposity assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp3148","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T10:50:41Z","timestamp":1488365441000},"page":"577-586","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Changes in Abdominal Fat following Antiretroviral Therapy Initiation in HIV-Infected Individuals Correlate with Waist Circumference and Self-Reported Changes"],"prefix":"10.1177","volume":"22","author":[{"given":"Priya","family":"Bhagwat","sequence":"first","affiliation":[{"name":"Present address: Center for HIV Identification, Prevention, and Treatment Services (CHIPTS), University of California, Los Angeles, Los Angeles, CA, USA"},{"name":"Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ighovwerha","family":"Ofotokun","sequence":"additional","affiliation":[{"name":"Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace A","family":"McComsey","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine, Case Western University, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd T","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlee","family":"Moser","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A","family":"Sugar","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S","family":"Currier","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"bibr1-IMP3148","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12381"},{"key":"bibr2-IMP3148","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.189624"},{"key":"bibr3-IMP3148","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-012-0519-0"},{"key":"bibr4-IMP3148","first-page":"112","volume":"14","author":"Domingo P.","year":"2012","journal-title":"AIDS Rev"},{"key":"bibr5-IMP3148","doi-asserted-by":"publisher","DOI":"10.1007\/s12170-013-0298-9"},{"key":"bibr6-IMP3148","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir324"},{"key":"bibr7-IMP3148","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu898"},{"key":"bibr8-IMP3148","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2012.02409.x"},{"key":"bibr9-IMP3148","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.067264"},{"key":"bibr10-IMP3148","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.047787"},{"key":"bibr11-IMP3148","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675355"},{"key":"bibr12-IMP3148","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.06.011"},{"key":"bibr13-IMP3148","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-011-9898-y"},{"key":"bibr14-IMP3148","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2010.543885"},{"key":"bibr15-IMP3148","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32834884e6"},{"key":"bibr16-IMP3148","first-page":"537","volume":"36","author":"Amato M.C.","year":"2013","journal-title":"J Endocrinol Invest"},{"key":"bibr17-IMP3148","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.3.471"},{"key":"bibr18-IMP3148","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-13-25"},{"key":"bibr19-IMP3148","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800929"},{"key":"bibr20-IMP3148","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90676-9"},{"key":"bibr21-IMP3148","doi-asserted-by":"publisher","DOI":"10.1310\/hct1005-314"},{"key":"bibr22-IMP3148","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-11-26"},{"key":"bibr23-IMP3148","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200301010-00015"},{"key":"bibr24-IMP3148","unstructured":"Haubrich R.H., Riddler S.A., DiRienzo G. Clinical associations of extremity fat loss from ACTG 5142: a prospective, randomized, Phase III trial of NRTI- PI- and NNRTI-sparing regimens for antiretroviral therapy (ART) of naive, HIV-1 infected subjects.\n                      15th Conference on Retroviruses and Opportunistic Infections\n                      . 3\u20136 February 2008, Boston, MA, USA."},{"key":"bibr25-IMP3148","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1084"},{"key":"bibr26-IMP3148","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ193"},{"key":"bibr27-IMP3148","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835ce27e"},{"key":"bibr28-IMP3148","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ327"},{"key":"bibr29-IMP3148","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318295eb1d"},{"key":"bibr30-IMP3148","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw017"},{"key":"bibr31-IMP3148","unstructured":"CDC. About adult BMI. (Accessed 14 July 2015.) Available from http:\/\/www.cdc.gov\/healthyweight\/assessing\/bmi\/adult_bmi\/."},{"key":"bibr32-IMP3148","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj111"},{"key":"bibr33-IMP3148","first-page":"72","volume":"22","author":"Wen M.","year":"2012","journal-title":"Ethn Dis"},{"key":"bibr34-IMP3148","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckp228"},{"key":"bibr35-IMP3148","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12085"},{"key":"bibr36-IMP3148","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072375"},{"key":"bibr37-IMP3148","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025032"},{"key":"bibr38-IMP3148","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/ajcn\/85.5.1197","volume":"85","author":"Klein S.","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"bibr39-IMP3148","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000479"},{"key":"bibr40-IMP3148","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2015.0147"},{"key":"bibr41-IMP3148","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0275"},{"key":"bibr42-IMP3148","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-014-0175-4"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:52:18Z","timestamp":1777380738000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP3148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,1]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.3851\/IMP3148"],"URL":"https:\/\/doi.org\/10.3851\/imp3148","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,1]]}}}