{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:35:56Z","timestamp":1779233756144,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A complete virological response is closely related to the long-term outcome of patients with chronic hepatitis B and prevention of emerging HBV mutations. We aimed to evaluate the efficacy of tenofovir disoproxil fumarate (TDF) monotherapy compared to entecavir-adefovir dipivoxil (ETV-ADV) combination therapy in patients with suboptimal responses to long-term lamivudine-adefovir dipivoxil (LAM-ADV) therapy for nucleoside analogue-resistant chronic hepatitis B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients ( n=60) were randomized to TDF monotherapy or ETV-ADV combination therapy for 96 weeks. All patients had the rt204I\/V mutation and serum HBV DNA was measured (&gt;60 IU\/ml) during LAM-ADV therapy. The primary end point was a complete virological response (HBV DNA &lt;20 IU\/ml) at week 96.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median duration of prior LAM-ADV rescue therapy was 43 (7\u2013108) months. A complete virological response was achieved in 86.6% and 53.3% of patients in the TDF and ETV-ADV groups, respectively, at week 96 ( P=0.005). Reduction in serum HBV DNA was significantly greater in the TDF group than in ETV-ADV group (-3.2 \u00b11.2 versus -2.6 \u00b11.2; P=0.01). Hepatitis B e antigen loss (22.2% versus 16.6%; P=0.731) and biochemical responses (76.7% versus 73.3%; P=0.766) were not different between the TDF and ETV-ADV groups. No newly emerged mutations were detected. Both therapies demonstrated favourable safety profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TDF therapy achieved a better complete virological response than ETV-ADV therapy in chronic hepatitis B patients with suboptimal response to long-term LAM-ADV rescue therapy. (KCT0000627).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp3169","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T05:49:18Z","timestamp":1493012958000},"page":"219-227","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Tenofovir Disoproxil Fumarate Monotherapy is Superior to Entecavir-Adefovir Combination Therapy in Patients with Suboptimal Response to Lamivudine-Adefovir Therapy for Nucleoside-Resistant HBV: A 96-Week Prospective Multicentre Trial"],"prefix":"10.1177","volume":"23","author":[{"given":"Sae Hwan","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gab Jin","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Gyune","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soung Won","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boo Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baek Gyu","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Don","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Won","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University Seoul Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Hyun","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Yeob","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Hanyang University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chungnam National University Hospital, Daejeon, 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