{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:38:54Z","timestamp":1790667534623,"version":"4.1.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>Hepatitis E virus (HEV) can induce chronic infections in the case of immunosuppression, which are sometimes not cured with ribavirin. Furthermore, sofosbuvir is a highly potent inhibitor of HCV polymerase and was shown to inhibit HEV genotype-3 replication in vitro. We report here the outcome of sofosbuvir\/ribavirin therapy on a chronic HEV infection in a heart transplant recipient non-responder to ribavirin. After 24 weeks, the regimen failed to cure the persistent HEV infection, highlighting the need of therapeutic options for HEV-infected immunosuppressed patients.<\/jats:p>","DOI":"10.3851\/imp3227","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T05:33:37Z","timestamp":1520228017000},"page":"463-465","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Chronic Hepatitis E in a Heart Transplant Patient: Sofosbuvir and Ribavirin Regimen Not Fully Effective"],"prefix":"10.1177","volume":"23","author":[{"given":"Eve","family":"Todesco","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d'\u00e9pid\u00e9miologie et de Sant\u00e9 Publique (IPLESP UMRS 1136), Paris, France"},{"name":"Department of Virology, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Mazzola","sequence":"additional","affiliation":[{"name":"APHP, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Unit\u00e9 M\u00e9dicale de Transplantation H\u00e9patique, H\u00e9pato-Gastro-Enterologie, UPMC Paris VI, Boulevard de l'H\u00f4pital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepideh","family":"Akhavan","sequence":"additional","affiliation":[{"name":"Department of Virology, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"},{"name":"Sorbonne Universit\u00e9s, UPMC Univ Paris 06, CIMI-Paris UMRS CR7, Inserm U1135, PVI Team, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Abravanel","sequence":"additional","affiliation":[{"name":"CHU Toulouse, H\u00f4pital Purpan, Laboratoire de virologie, National Reference Center for Hepatitis E, Toulouse, 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