{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:55:15Z","timestamp":1777452915845,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Haemorrhagic cystitis (HC) is usually a serious complication in allogeneic haematopoietic stem cell transplantation (allo-HSCT) recipients. In this study, our aim was to define risk factors and outcomes for patients with HC in an allo-HSCT setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively evaluated 249 allo-HSCTs performed between 2011 and 2016 in our centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HC was diagnosed in 98 patients (39%) at a median of 119 days (range 5\u2013580) and 91 (93%) of the patients had late onset disease. In univariate analysis, HC was related to cytomegalovirus (CMV) reactivation ( P&lt;0.001) and BK viraemia ( P&lt;0.001); in multivariate analysis, the presence of CMV reactivation was determined to be an independent risk factor (odds ratio: 22.1; 95% CI 1.73, 282.44; P=0.017). There was no association detected between acute graft versus host disease and patients diagnosed with HC within 100 days of transplant. HC was significantly increased by the presence of myelo-ablative conditioning (odds ratio: 31.28; 95% CI 3.98, 246.87; P=0.001) and BK viraemia (odds ratio: 3.93; 95% Cl 1.10, 14.05; P=0.035) in patients with HC grade II and beyond. Forced hydration was recommended in all patients with grade I HC. Patients with HC and clots were treated with continuous bladder irrigation, and 14 of 44 patients with BK viraemia received cidofovir \u00b1 ribavirin. Eight of these patients (57%) responded to treatment. Refractory HC was detected in 17 patients (17%) and resolved by a variety of procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that CMV reactivation is associated with increased risk of HC in multivariate analysis, however, this result is not confirmed in patients with HC grade II and beyond.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp3252","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T06:08:58Z","timestamp":1530684538000},"page":"647-653","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Is cytomegalovirus a risk factor for haemorrhagic cystitis in allogeneic haematopoietic stem cell transplantation recipients?"],"prefix":"10.1177","volume":"23","author":[{"given":"Erden","family":"Atilla","sequence":"first","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merih","family":"Yalciner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar Ataca","family":"Atilla","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Ates","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Yuzuncu Yil University, Van, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinem Civriz","family":"Bozdag","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem Kurt","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selami Kocak","family":"Toprak","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Gunduz","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Ozen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdi","family":"Akan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taner","family":"Demirer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onder","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Ilhan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Ankara University School of Medicine, Ankara, 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