{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:55:24Z","timestamp":1777452924773,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Despite very high efficacies of direct-acting antivirals (DAAs) reported in clinical trials, treatment failure in real-life practice can occur in 5\u201310% of cases and is mostly associated with emergence of resistance-associated substitutions (RASs). Little is known about the efficacy of retreatment in these patients, especially in those with decompensated cirrhosis, and only a few retreatment studies have been performed so far. Here we present case reports of successful sofosbuvir-based treatment in patients with advanced class B cirrhosis with prior pegylated interferon\/ribavirin and all-oral DAA failure with multiclass drug resistance. HCV resistance testing at failure was performed to guide the choice of salvage therapy.<\/jats:p>","DOI":"10.3851\/imp3266","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T13:57:27Z","timestamp":1538143047000},"page":"705-708","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Sofosbuvir-based salvage therapy for HCV infection in cirrhotic patients with DAA failure and multidrug resistance"],"prefix":"10.1177","volume":"23","author":[{"given":"Dzhamal T","family":"Abdurakhmanov","sequence":"first","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teona P","family":"Rozina","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"},{"name":"Lomonosov Moscow State University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena N","family":"Nikulkina","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina A","family":"Nabatchikova","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir P","family":"Chulanov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"},{"name":"Central Research Institute of Epidemiology, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey V","family":"Moiseev","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University, Moscow, Russia"},{"name":"Lomonosov Moscow State University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,1]]},"reference":[{"key":"bibr1-IMP3266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.09.011"},{"key":"bibr2-IMP3266","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61059-X"},{"key":"bibr3-IMP3266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.10.005"},{"key":"bibr4-IMP3266","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402869"},{"key":"bibr5-IMP3266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.008"},{"key":"bibr6-IMP3266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"bibr7-IMP3266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.019"},{"key":"bibr8-IMP3266","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(16)00128-8"},{"key":"bibr9-IMP3266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.08.012"},{"key":"bibr10-IMP3266","unstructured":"P\u00e9rez A.B., Chueca N., Garc\u00eda-Deltoro M. Retreatment options after failing a first line of DAAs against hepatitis C virus.\n                      The Annual Conference on Retroviruses and Opportunistic Infections (CROI)\n                      . 13\u201316 February 2017, Seattle, WA, USA. Abstract 566."},{"key":"bibr11-IMP3266","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12645"},{"key":"bibr12-IMP3266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.010"},{"key":"bibr13-IMP3266","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613512"},{"key":"bibr14-IMP3266","unstructured":"Wyles D., Weiland O., Yao B. Retreatment of hepatitis C infection in patients who failed glecaprevir\/pibrentasvir.\n                      Conference on Retroviruses and Opportunistic Infections (CROI)\n                      . 4\u20137 March 2018, Boston, MA, USA. Abstract 127."}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:52:37Z","timestamp":1777380757000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP3266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,1]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.3851\/IMP3266"],"URL":"https:\/\/doi.org\/10.3851\/imp3266","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,1]]}}}