{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:56:25Z","timestamp":1777452985764,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Cytomegalovirus (CMV) infections can induce severe complications in immunosuppressed patients. Currently, ganciclovir represents the preferred treatment option; however, in patients with resistance or toxicity related to ganciclovir, the therapeutic options are limited.<\/jats:p>\n                  <jats:p>Cellular immunity plays an important role in the control of viral infections. Adoptive T-cell therapy can contribute to recovering immunological function in immunosuppressed patients. Selective T-cell depletion targeting CD45RA enhances early T-cell recovery and can represent a salvage therapy. In this study, an immunocompromised non-transplanted patient with CMV disease and toxicity to conventional therapy was successfully treated by adoptive transfer of CD45RA-depleted T-cells.<\/jats:p>","DOI":"10.3851\/imp3307","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T10:00:23Z","timestamp":1553594423000},"page":"313-319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Adoptive T-cell Therapy with CD45RA-depleted Donor in the Treatment of Cytomegalovirus Disease in Immunocompromised Non-transplant Patients"],"prefix":"10.1177","volume":"24","author":[{"given":"Jose R","family":"Yuste","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"},{"name":"Department of Internal Medicine, Cl\u00ednica Universidad de Navarra, Pamplona, 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