{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:57:03Z","timestamp":1777453023532,"version":"3.51.4"},"reference-count":140,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pretreatment and acquired drug resistance mutations (DRMs) can limit antiretroviral therapy effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We review prevalence of DRMs with resistance to nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), focusing on lamivudine and rilpivirine, from 127 articles with &gt;100,000 individuals with HIV-1 infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Estimated global prevalence of pretreatment resistance to any NRTI was 4% and to any NNRTI was 6%. Most prevalent DRMs resistant to lamivudine or rilpivirine were at positions E138 (4%), V179 (1%) and M184 (1%). Estimated acquired DRM prevalence was 58% for any NRTIs and 67% for any NNRTIs, most frequently at positions M184 (58%) and Y181 (21%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review suggests low risk of lamivudine-or rilpivirine-resistant mutations in treatment-naive, HIV-1-infected individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp3331","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T10:36:56Z","timestamp":1568111816000},"page":"393-404","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence of Pretreatment and Acquired HIV-1 Mutations Associated with Resistance to Lamivudine or Rilpivirine: A Systematic Review"],"prefix":"10.1177","volume":"24","author":[{"given":"Vani","family":"Vannappagari","sequence":"first","affiliation":[{"name":"ViiV Healthcare, Research Triangle Park, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh","family":"Ragone","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Research Triangle Park, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassidy","family":"Henegar","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Research Triangle Park, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"van Wyk","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Brentford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dannae","family":"Brown","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Abbotsford, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Demarest","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Research Triangle Park, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Quercia","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Brentford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marty St.","family":"Clair","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Research Triangle Park, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Underwood","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Research Triangle Park, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M","family":"Gatell","sequence":"additional","affiliation":[{"name":"Hospital Clinic\/IDIBAPS, University of Barcelona, Barcelona, Spain"},{"name":"ViiV Healthcare, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemiek","family":"de Ruiter","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Brentford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Aboud","sequence":"additional","affiliation":[{"name":"ViiV Healthcare, Brentford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"bibr1-IMP3331","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61809-7"},{"key":"bibr2-IMP3331","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32835ba6b1"},{"key":"bibr3-IMP3331","author":"HIV\/AIDS JUNPo.","year":"2017","journal-title":"Global AIDS Update."},{"key":"bibr4-IMP3331","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz178"},{"key":"bibr5-IMP3331","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200311010-00004"},{"key":"bibr6-IMP3331","doi-asserted-by":"publisher","DOI":"10.1086\/427192"},{"key":"bibr7-IMP3331","unstructured":"Panel on Antiretroviral Guidelines for Adults and Adolescents. 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