{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:24:33Z","timestamp":1782951873979,"version":"3.54.5"},"reference-count":43,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic hepatitis B (CHB) treatment adherence has been poorly studied worldwide. We evaluated long-term virological and adherence outcomes to antiviral treatment in CHB patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective 183 Brazilian CHB patient cohort treated with monotherapy or combination adefovir dipivoxil, entecavir, lamivudine and\/or tenofovir disoproxil fumarate was studied in a reference tertiary centre. Treatment adherence was evaluated by a validated questionnaire named \u2018Assessment of Adherence to Antiviral Therapy Questionnaire\u2019 (CEAT-HBV) within three yearly periods (2010\/2011, 2013\/2014 and 2014\/2015).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CEAT-HBV identified 43% (79\/183) patients with non-adherence to antiviral treatment and among them, 67% (53\/79) were viral load positive. The main causes associated with non-response to antiviral treatment were drug resistance variants followed by non-adherence, insufficient treatment duration and other causes. Single-dose pharmacokinetics demonstrated 35% (23\/65) antiviral non-adherence. 2 years after the first assessment, the CEAT-HBV indicated that 71% (101\/143) of subjects adhered to treatment (per-protocol population). However, 21% (40\/183) of the patients could not be evaluated and were excluded. The main reasons for exclusion were death (20\/183), 11 out 20 deaths due to hepatocellular carcinoma. HBV booklet was used for medical education. The third CEAT-HBV assessment (2014\/2015) showed that 83% (112\/135) patients were compliant with treatment adherence (per-protocol population). Long-term evaluation showed that adherence rate based on CEAT-HBV continue to increase after 4-years ( P&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results highlight the importance of CHB therapy adherence assessment monitoring. Long-term adherence outcomes were dynamic and it is possible to increase the migration rate to adherence\/HBV-DNA-negative group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp3338","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T09:19:21Z","timestamp":1575451161000},"page":"567-579","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Long-term Virological and Adherence Outcomes to Antiviral Treatment in a 4-year Cohort Chronic HBV Study"],"prefix":"10.1177","volume":"24","author":[{"given":"Rodrigo M","family":"Abreu","sequence":"first","affiliation":[{"name":"Divis\u00e3o de Gastroenterologia e Hepatologia Cl\u00ednica do Hospital das Cl\u00ednicas HCFMUSP, Departamento de Gastroenterologia da Faculdade de Medicina, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"},{"name":"Divis\u00e3o de Farm\u00e1cia do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leda C","family":"Bassit","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Pharmacology, Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Tao","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Pharmacology, Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Pharmacology, Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline S","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Gastroenterologia e Hepatologia Cl\u00ednica do Hospital das Cl\u00ednicas HCFMUSP, Departamento de Gastroenterologia da Faculdade de Medicina, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia CA","family":"Hori","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Farm\u00e1cia do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia M","family":"Ganova-Raeva","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury","family":"Khudyakov","sequence":"additional","affiliation":[{"name":"Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond F","family":"Schinazi","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemical Pharmacology, Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flair J","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Gastroenterologia e Hepatologia Cl\u00ednica do Hospital das Cl\u00ednicas HCFMUSP, Departamento de Gastroenterologia da Faculdade de Medicina, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzane K","family":"Ono","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Gastroenterologia e Hepatologia Cl\u00ednica do Hospital das Cl\u00ednicas HCFMUSP, Departamento de Gastroenterologia da Faculdade de Medicina, Universidade de Sao Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"key":"bibr1-IMP3338","unstructured":"WHO. Hepatitis B. 2018. (Accessed 24 August 2019.) Available from https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-b."},{"key":"bibr2-IMP3338","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2016.07.001"},{"key":"bibr3-IMP3338","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.33"},{"key":"bibr4-IMP3338","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61425-1"},{"key":"bibr5-IMP3338","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26301"},{"key":"bibr6-IMP3338","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13272"},{"key":"bibr7-IMP3338","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12418"},{"key":"bibr8-IMP3338","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11100"},{"key":"bibr9-IMP3338","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-015-0101-y"},{"key":"bibr10-IMP3338","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.016"},{"key":"bibr11-IMP3338","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01494.x"},{"key":"bibr12-IMP3338","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1944"},{"key":"bibr13-IMP3338","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"},{"key":"bibr14-IMP3338","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"bibr15-IMP3338","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-012-9365-4"},{"key":"bibr16-IMP3338","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24318"},{"key":"bibr17-IMP3338","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.053"},{"key":"bibr18-IMP3338","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21189"},{"key":"bibr19-IMP3338","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807093390201"},{"key":"bibr20-IMP3338","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051287"},{"key":"bibr21-IMP3338","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.026"},{"key":"bibr22-IMP3338","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.025"},{"key":"bibr23-IMP3338","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021812"},{"key":"bibr24-IMP3338","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020681"},{"key":"bibr25-IMP3338","doi-asserted-by":"publisher","DOI":"10.1086\/380398"},{"key":"bibr26-IMP3338","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12416"},{"key":"bibr27-IMP3338","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i32.9588"},{"key":"bibr28-IMP3338","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31000-2"},{"key":"bibr29-IMP3338","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v4.i2.43"},{"key":"bibr30-IMP3338","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2012.722648"},{"key":"bibr31-IMP3338","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.04.006"},{"key":"bibr32-IMP3338","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02213-16"},{"key":"bibr33-IMP3338","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.033"},{"key":"bibr34-IMP3338","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3365"},{"key":"bibr35-IMP3338","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109652"},{"key":"bibr36-IMP3338","first-page":"844","volume":"20","author":"Cantudo-Cuenca M.R.","year":"2014","journal-title":"J Manag Care Spec Pharm"},{"key":"bibr37-IMP3338","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2016.06.012"},{"key":"bibr38-IMP3338","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29537"},{"key":"bibr39-IMP3338","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26180"},{"key":"bibr40-IMP3338","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.01.002"},{"key":"bibr41-IMP3338","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.03.024"},{"key":"bibr42-IMP3338","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13377"},{"key":"bibr43-IMP3338","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3851\/IMP3338","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:52:50Z","timestamp":1777380770000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP3338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.3851\/IMP3338"],"URL":"https:\/\/doi.org\/10.3851\/imp3338","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,1]]}}}