{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:57:26Z","timestamp":1777453046076,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Due to the limitations of current antiviral therapies because of drug resistance and the emergence of new circulating viral strains, novel effective antivirals are urgently needed. Results of the previous drug repurposing by virtual screening of DrugBank revealed the anticholinergic drug cycrimine as a possible inhibitor of the influenza virus infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study we examined the potential antiviral activity of cycrimine in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The experimental results showed the anti-influenza activity of cycrimine against two different influenza A subtypes in cell culture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of this study suggest cycrimine as a potential therapeutic agent for influenza.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp3348","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T06:21:46Z","timestamp":1582870906000},"page":"589-593","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>In vitro<\/i>\n                    Anti-influenza Activity of\n                    <i>in silico<\/i>\n                    Repurposed Candidate Drug Cycrimine"],"prefix":"10.1177","volume":"24","author":[{"given":"Stanislava","family":"Matejin","sequence":"first","affiliation":[{"name":"Center for Advanced Heart Failure (ACTAT), Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalya","family":"Bukreyeva","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Draginja","family":"Radosevic","sequence":"additional","affiliation":[{"name":"Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Sencanski","sequence":"additional","affiliation":[{"name":"Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Mantlo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veljko","family":"Veljkovic","sequence":"additional","affiliation":[{"name":"Biomed Protection, Galveston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Glisic","sequence":"additional","affiliation":[{"name":"Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Paessler","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA"},{"name":"Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"key":"bibr1-IMP3348","unstructured":"World Health Organization. Influenza (seasonal) factsheet (2018). (Accessed 1 August 2019.) Available from http:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/influenza- (seasonal)."},{"key":"bibr2-IMP3348","first-page":"419","volume-title":"Influenza Textbook","author":"Bridges C."},{"key":"bibr3-IMP3348","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0899-1"},{"key":"bibr4-IMP3348","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2016.11.008"},{"key":"bibr5-IMP3348","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2016.06.001"},{"key":"bibr6-IMP3348","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2019.01.006"},{"key":"bibr7-IMP3348","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198209023071002"},{"key":"bibr8-IMP3348","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00190-4"},{"key":"bibr9-IMP3348","first-page":"44","volume":"55","author":"CDC.","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"bibr10-IMP3348","doi-asserted-by":"crossref","first-page":"e0119115","DOI":"10.1371\/journal.pone.0119115","volume":"10","author":"Dong G.","year":"2015","journal-title":"PLoS One"},{"key":"bibr11-IMP3348","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2017.22.47.17-00731"},{"key":"bibr12-IMP3348","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00067"},{"key":"bibr13-IMP3348","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2012.638280"},{"key":"bibr14-IMP3348","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq012"},{"key":"bibr15-IMP3348","first-page":"1071","volume":"44","author":"Kafer J.P.","year":"1957","journal-title":"Prensa Med Argent"},{"key":"bibr16-IMP3348","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26102"},{"key":"bibr17-IMP3348","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01547.x"},{"key":"bibr18-IMP3348","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0548-y"},{"key":"bibr19-IMP3348","doi-asserted-by":"publisher","DOI":"10.7150\/thno.17071"},{"key":"bibr20-IMP3348","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.06.007"},{"key":"bibr21-IMP3348","doi-asserted-by":"publisher","DOI":"10.1021\/ci700078n"},{"key":"bibr22-IMP3348","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.6436.1"},{"key":"bibr23-IMP3348","doi-asserted-by":"publisher","DOI":"10.1038\/nature18615"},{"key":"bibr24-IMP3348","doi-asserted-by":"publisher","DOI":"10.2741\/4627"},{"key":"bibr25-IMP3348","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666151002113426"},{"key":"bibr26-IMP3348","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2011.03.003"},{"key":"bibr27-IMP3348","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2018.04.004"}],"container-title":["Antiviral Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3851\/IMP3348","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3851\/IMP3348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:52:51Z","timestamp":1777380771000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3851\/IMP3348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.3851\/IMP3348"],"URL":"https:\/\/doi.org\/10.3851\/imp3348","relation":{},"ISSN":["1359-6535","2040-2058"],"issn-type":[{"value":"1359-6535","type":"print"},{"value":"2040-2058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,1]]}}}