{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:22:52Z","timestamp":1780582972017,"version":"3.54.1"},"reference-count":52,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study investigated survival in people living with HIV being followed-up from 5 and 10 years after antiretroviral therapy (ART) initiation in a multi-country Asian cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included patients in follow-up &gt;5 years after ART initiation. Factors associated with mortality beyond 5 and 10 years on ART were analysed using competing risk regression with time-updated variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 13,495 patients retained after 5 years on ART, 279 subsequently died (0.56\/100 person-years). Increased mortality was associated with age &gt;50 years (sub-hazard ratio [sHR] 2.24, 95% CI 1.58, 3.15, compared with \u226440 years), HIV exposure through injecting drug use (sHR 2.17, 95% CI 1.32, 3.56), HIV viral load \u22651,000 copies\/ml: sHR 1.52, 95% CI 1.05, 2.21, compared with &lt;400), regimen (second-line regimen: sHR 2.11, 95% CI 1.52, 2.94, and third-line regimen: sHR 2.82, 95% CI 2.00, 3.98, compared with first-line regimen), HBV coinfection (sHR 2.23, 95% CI 1.49, 3.33), fasting plasma glucose \u2265126 mg\/dl (sHR 1.98, 95% CI 1.22, 3.21, compared with &lt;100 mg\/dl) and estimated glomerular filtration rate &lt;60 ml\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      (sHR 2.57, 95% CI 1.56, 4.22). Decreased mortality was associated with transmission through male-to-male sexual contact (sHR 0.44, 95% CI 0.22, 0.88, compared with heterosexual transmission) and higher CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell count (200\u2013349 cells\/\u03bcl: sHR 0.27, 95% CI 0.20, 0.38, 350\u2013499 cells\/\u03bcl: sHR 0.10, 95% CI 0.07, 0.16 and \u2265500 cells\/\u03bcl: sHR 0.09, 95% CI 0.06, 0.13, compared with &lt;200 cells\/\u03bcl). Results after 10 years were similar, but most associations were weaker due to limited power.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Next to preventing ART failure, HIV programmes should carefully monitor and treat comorbidi-ties, including hepatitis, kidney disease and diabetes, to optimize survival after long-term ART exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp3358","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T10:13:10Z","timestamp":1588673590000},"page":"131-142","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Survival after Long-Term ART Exposure: Findings from an Asian Patient Population Retained in Care beyond 5 Years on ART"],"prefix":"10.1177","volume":"25","author":[{"name":"Asia-Pacific IeDEA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimke","family":"Bijker","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney, Kensington, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasisopin","family":"Kiertiburanakul","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagalingeswaran","family":"Kumarasamy","sequence":"additional","affiliation":[{"name":"Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Pujari","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ly P","family":"Sun","sequence":"additional","affiliation":[{"name":"National Center for HIV\/AIDS, Dermatology & STDs, and University of Health Sciences, Phnom Penh, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oon T","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man P","family":"Lee","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Y","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinh V","family":"Nguyen","sequence":"additional","affiliation":[{"name":"National Hospital for Tropical Diseases, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu J","family":"Chan","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuti P","family":"Merati","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do D","family":"Cuong","sequence":"additional","affiliation":[{"name":"Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Ross","sequence":"additional","affiliation":[{"name":"TREAT Asia, amfAR \u2013 The Foundation for AIDS Research, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awachana","family":"Jiamsakul","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Sydney, Kensington, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"bibr1-IMP3358","volume-title":"Global AIDS update 2016.","author":"Joint United Nations Programme on HIV\/AIDS 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