{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:19:41Z","timestamp":1778581181846,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Antiviral Therapy"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The baseline susceptibility of primary HIV-2 to maraviroc (MVC) and other entry inhibitors is currently unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The susceptibility of 19 HIV-2 isolates obtained from asymptomatic and AIDS patients and seven HIV-1 clinical isolates to the fusion inhibitors enfuvirtide (ENF) and T-1249, and to the coreceptor antagonists AMD3100, TAK-779 and MVC, was measured using a TZM-bl cell-based assay. The 50% inhibitory concentration (IC\n                      <jats:sub>50<\/jats:sub>\n                      ), 90% inhibitory concentration (IC\n                      <jats:sub>90<\/jats:sub>\n                      ) and dose\u2013response curve slopes were determined for each drug.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ENF and T-1249 were significantly less active on HIV-2 than on HIV-1 (211- and 2-fold, respectively). AMD3100 and TAK-779 inhibited HIV-2 and HIV-1 CXCR4 tropic (X4) and CCR5 tropic (R5) variants with similar IC\n                      <jats:sub>50<\/jats:sub>\n                      and IC\n                      <jats:sub>90<\/jats:sub>\n                      values. MVC, however, inhibited the replication of R5 HIV-2 variants with significantly higher IC\n                      <jats:sub>90<\/jats:sub>\n                      values (42.7 versus 9.7 nM; P&lt;0.0001) and lower slope values (0.7 versus 1.3; P&lt;0.0001) than HIV-1. HIV-2 R5 variants derived from AIDS patients were significantly less sensitive to MVC than variants from asymptomatic patients, this being inversely correlated with the absolute number of CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>T-1249 is a potent inhibitor of HIV-2 replication indicating that new fusion inhibitors might be useful to treat HIV-2 infection. Coreceptor antagonists TAK-779 and AMD3100 are also potent inhibitors of HIV-2 replication. The reduced sensitivity of R5 variants to MVC, especially in severely immunodeficient patients, indicates that the treatment of HIV-2-infected patients with MVC might require higher dosages than those used in HIV-1 patients, and should be adjusted to the disease stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3851\/imp1996","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T12:59:41Z","timestamp":1327496381000},"page":"565-570","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["Baseline Susceptibility of Primary HIV-2 to Entry Inhibitors"],"prefix":"10.1177","volume":"17","author":[{"given":"Pedro","family":"Borrego","sequence":"first","affiliation":[{"name":"URIA-CPM, Faculdade de Farm\u00e1cia de Lisboa, Lisbon, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Caparica, Portugal"}]},{"given":"Rita","family":"Calado","sequence":"additional","affiliation":[{"name":"URIA-CPM, Faculdade de Farm\u00e1cia de Lisboa, Lisbon, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Caparica, Portugal"}]},{"given":"Jos\u00e9 M","family":"Marcelino","sequence":"additional","affiliation":[{"name":"Unidade de Ensino e Investiga\u00e7\u00e3o de Microbiologia M\u00e9dica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal"}]},{"given":"In\u00eas","family":"B\u00e1rtolo","sequence":"additional","affiliation":[{"name":"URIA-CPM, Faculdade de Farm\u00e1cia de Lisboa, Lisbon, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Caparica, Portugal"}]},{"given":"Cheila","family":"Rocha","sequence":"additional","affiliation":[{"name":"URIA-CPM, Faculdade de Farm\u00e1cia de Lisboa, Lisbon, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Caparica, Portugal"}]},{"given":"Patr\u00edcia","family":"Cavaco-Silva","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Caparica, Portugal"}]},{"given":"Manuela","family":"Doroana","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas, Hospital de Santa Maria, Lisbon, Portugal"}]},{"given":"Francisco","family":"Antunes","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas, Hospital de Santa Maria, Lisbon, Portugal"}]},{"given":"Fernando","family":"Maltez","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas, Hospital de Curry Cabral, Lisbon, Portugal"}]},{"given":"Umbelina","family":"Caixas","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Medicina 1.4, Hospital de S Jos\u00e9 and Faculdade de Ciencias M\u00e9dicas, FCM-Nova, Centro de Estudos de Doen\u00e7as Cr\u00f3nicas, Lisbon, Portugal"}]},{"given":"Helena","family":"Barroso","sequence":"additional","affiliation":[{"name":"URIA-CPM, Faculdade de Farm\u00e1cia de Lisboa, Lisbon, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Caparica, Portugal"}]},{"given":"Nuno","family":"Taveira","sequence":"additional","affiliation":[{"name":"URIA-CPM, Faculdade de Farm\u00e1cia de Lisboa, Lisbon, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Superior de Ci\u00eancias da Sa\u00fade Egas Moniz, Monte de Caparica, Caparica, Portugal"},{"name":"Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisbon, Portugal"}]}],"member":"179","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"bibr1-IMP1996","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00154-09"},{"key":"bibr2-IMP1996","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81259-0"},{"key":"bibr3-IMP1996","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.9.7795-7804.1999"},{"key":"bibr4-IMP1996","first-page":"463704","volume":"2011","author":"Peterson K.","year":"2011","journal-title":"Aids Res 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