{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:44:54Z","timestamp":1790095494096,"version":"4.0.1"},"reference-count":0,"publisher":"Journal of Infection in Developing Countries","issue":"01","license":[{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Infect Dev Ctries"],"abstract":"<jats:p>Introduction: Hepatitis D virus (HDV) is a satellite virus of hepatitis B virus (HBV). An estimated 5% of HBV infected individuals worldwide have HDV infection. There is paucity of studies in Nigeria on the burden of HDV infection. This study aimed at determining the prevalence rate of HDV antibodies among individuals with chronic hepatitis B (CHB) infection and comparing the liver function test (LFT) and disease severity among the anti-HDV positive (anti-HDV+) and anti-HDV negative (anti-HDV-) individuals.\r\nMethodology: A cross-sectional study of 180 CHB infected individuals who were clinically evaluated and tested for HDV antibodies using the Enzyme-linked Immunoassay method. Their LFT profile and Child-Turcotte-Pugh (CTP) were also assessed. Data were analyzed using the SPSS version 17.\r\nResults: Their mean age was 35.2 \u00b1 10.4 years. There were 150 (83.3%) and 30 (16.7%) individuals with uncomplicated and complicated CHB infection respectively. Thirty-four (18.9%) of the participants were anti-HDV+. The mean serum ALT, AST, albumin and INR of the anti-HDV+ subjects were 16.5 \u00b1 13.8 IU\/L, 26.3 \u00b1 32.6 IU\/L, 38.9 \u00b1 7.6 g\/L, and 1.2 \u00b1 0.2 respectively. The mean values for the same parameters of the anti-HDV- subjects were 10.8 \u00b1 9.5 IU\/L, 13.4 \u00b1 11.2 IU\/L, 41.4 \u00b1 6.0 g\/L and 1.1 \u00b1 0.2 respectively (p &lt; 0.05). The mean CTP scores in the anti-HDV+ and anti-HDV- subjects were 6.1 \u00b1 2.1 and 5.5 \u00b1 1.2 respectively (p= 0.03).\r\nConclusions: Anti-HDV sero-prevalence rate was 18.9% and anti-HDV+ CHB patients had worse LFT results compared to those who were anti-HDV\u2013.<\/jats:p>","DOI":"10.3855\/jidc.13127","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T20:39:09Z","timestamp":1612989549000},"page":"141-146","source":"Crossref","is-referenced-by-count":6,"title":["Hepatitis D virus antibodies and liver function profile among patients with chronic hepatitis B infection in Abuja, Nigeria"],"prefix":"10.3855","volume":"15","author":[{"given":"Lukman O","family":"Abdulkareem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A","family":"Ndububa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine O","family":"Uhunmwangho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thahir","family":"Yunusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2222","published-online":{"date-parts":[[2021,1,31]]},"container-title":["The Journal of Infection in Developing Countries"],"original-title":[],"link":[{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/13127\/2447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/download\/13127\/2447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T20:39:10Z","timestamp":1612989550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jidc.org\/index.php\/journal\/article\/view\/13127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,31]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2021,1,31]]}},"URL":"https:\/\/doi.org\/10.3855\/jidc.13127","relation":{},"ISSN":["1972-2680"],"issn-type":[{"value":"1972-2680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,31]]}}}